Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
sigma_EUR_WGS_EOAD_58_z_3_5 Exclusive	tier1_31	6.32e-01	9.04e-01	8.28e-01	1.22e-01
tier1_31 Exclusive	sigma_EUR_WGS_EOAD_58_z_3_5	5.26e-01	6.86e-01	6.50e-01	8.73e-01
sigma_EUR_WGS_EOAD_58_z_3_5 Exclusive	tier1_31 Exclusive	4.81e-01	7.92e-01	7.86e-01	1.86e-01
tier1_31 Exclusive	sigma_EUR_WGS_EOAD_58_z_3_5 Exclusive	4.72e-01	8.65e-01	6.73e-01	9.71e-01
sigma_EUR_WGS_EOAD_58_z_3_5 Exclusive	Overlap	8.32e-01	8.91e-01	9.90e-01	8.71e-01
tier1_31 Exclusive	Overlap	1.98e-02	1.98e-02	1.98e-02	1.98e-02
Overlap	Exclusives	2.05e-06	3.46e-07	4.33e-11	2.64e-07



Evaluating how well sigma_EUR_WGS_EOAD_58_z_3_5 genes are linked to tier1_31 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
sigma_EUR_WGS_EOAD_58_z_3_5 Exclusive	tier1_31	0.60	0.47	0.36	0.13	1.77
tier1_31 Exclusive	sigma_EUR_WGS_EOAD_58_z_3_5	0.51	0.86	1.04	0.64	0.09
sigma_EUR_WGS_EOAD_58_z_3_5 Exclusive	tier1_31 Exclusive	0.60	0.53	0.39	0.28	1.53
tier1_31 Exclusive	sigma_EUR_WGS_EOAD_58_z_3_5 Exclusive	0.50	0.47	0.64	0.43	0.14
sigma_EUR_WGS_EOAD_58_z_3_5 Exclusive	Overlap	0.62	0.22	0.04	0.00	0.37
tier1_31 Exclusive	Overlap	1.00	2.28	1.49	1.84	1.65
Overlap	Exclusives	0.65	1.66	5.33	2.50	4.80

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
sigma_EUR_WGS_EOAD_58_z_3_5 Exclusive	tier1_31	0.00	-0.15	0.39	0.06	0.48
tier1_31 Exclusive	sigma_EUR_WGS_EOAD_58_z_3_5	0.01	3.00	5.89	4.01	3.01
sigma_EUR_WGS_EOAD_58_z_3_5 Exclusive	tier1_31 Exclusive	0.00	-0.10	0.49	0.15	0.88
tier1_31 Exclusive	sigma_EUR_WGS_EOAD_58_z_3_5 Exclusive	0.00	0.21	0.82	0.25	0.25
sigma_EUR_WGS_EOAD_58_z_3_5 Exclusive	Overlap	0.00	-0.22	-0.27	-0.19	-0.19
tier1_31 Exclusive	Overlap	0.08	780.23	59.42	295.09	183.75
Overlap	Exclusives	0.04	18.42	98.68	29.38	62.15

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
sigma_EUR_WGS_EOAD_58_z_3_5 Exclusive	57	57	
tier1_31 Exclusive	30	29	MS4A
Overlap	1	1