Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
sigma_EUR_WGS_EOAD_58_z_3_5 Exclusive	Ismael_14_AD	1.70e-02	7.32e-02	9.01e-02	1.72e-03
Ismael_14_AD Exclusive	sigma_EUR_WGS_EOAD_58_z_3_5	3.72e-02	3.72e-03	1.88e-05	9.21e-03
sigma_EUR_WGS_EOAD_58_z_3_5 Exclusive	Ismael_14_AD Exclusive	5.62e-02	5.12e-02	1.58e-01	1.49e-02
Ismael_14_AD Exclusive	sigma_EUR_WGS_EOAD_58_z_3_5 Exclusive	1.18e-01	5.18e-03	1.95e-05	1.08e-02
sigma_EUR_WGS_EOAD_58_z_3_5 Exclusive	Overlap	1.39e-01	3.96e-01	3.76e-01	2.38e-01
Ismael_14_AD Exclusive	Overlap	1.98e-02	1.98e-02	1.98e-02	1.98e-02
Overlap	Exclusives	5.12e-04	5.76e-04	1.28e-04	1.90e-03



Evaluating how well sigma_EUR_WGS_EOAD_58_z_3_5 genes are linked to Ismael_14_AD genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
sigma_EUR_WGS_EOAD_58_z_3_5 Exclusive	Ismael_14_AD	0.78	2.11	2.85	1.55	4.05
Ismael_14_AD Exclusive	sigma_EUR_WGS_EOAD_58_z_3_5	0.59	4.68	3.16	3.84	2.41
sigma_EUR_WGS_EOAD_58_z_3_5 Exclusive	Ismael_14_AD Exclusive	0.78	1.65	2.26	1.37	3.38
Ismael_14_AD Exclusive	sigma_EUR_WGS_EOAD_58_z_3_5 Exclusive	0.59	4.30	3.38	3.42	2.45
sigma_EUR_WGS_EOAD_58_z_3_5 Exclusive	Overlap	0.81	1.71	1.10	1.19	1.24
Ismael_14_AD Exclusive	Overlap	1.00	5.72	1.56	2.14	1.75
Overlap	Exclusives	0.60	1.18	3.47	1.58	2.98

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
sigma_EUR_WGS_EOAD_58_z_3_5 Exclusive	Ismael_14_AD	0.00	3.83	1.36	2.28	2.68
Ismael_14_AD Exclusive	sigma_EUR_WGS_EOAD_58_z_3_5	0.01	9.84	13.54	10.32	10.07
sigma_EUR_WGS_EOAD_58_z_3_5 Exclusive	Ismael_14_AD Exclusive	0.00	2.94	0.96	0.83	0.69
Ismael_14_AD Exclusive	sigma_EUR_WGS_EOAD_58_z_3_5 Exclusive	0.00	3.20	3.29	2.21	2.33
sigma_EUR_WGS_EOAD_58_z_3_5 Exclusive	Overlap	0.00	0.92	0.24	-0.05	0.01
Ismael_14_AD Exclusive	Overlap	0.25	1713.15	403.56	296.39	55.23
Overlap	Exclusives	0.02	18.01	38.14	9.13	30.75

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
sigma_EUR_WGS_EOAD_58_z_3_5 Exclusive	57	57	
Ismael_14_AD Exclusive	13	13	
Overlap	1	1