Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
SAI balanced 0 Exclusive	EA balanced	3.12e-01	4.01e-01	4.36e-02	7.75e-02
EA balanced Exclusive	SAI balanced 0	7.95e-01	6.90e-01	9.07e-01	6.60e-02
SAI balanced 0 Exclusive	EA balanced Exclusive	3.32e-01	6.53e-01	8.09e-02	1.28e-01
EA balanced Exclusive	SAI balanced 0 Exclusive	5.31e-01	5.60e-01	7.26e-01	3.70e-02
SAI balanced 0 Exclusive	Overlap	4.28e-01	5.02e-01	3.57e-01	6.28e-01
EA balanced Exclusive	Overlap	6.02e-01	8.94e-01	7.29e-01	8.66e-01
Overlap	Exclusives	1.95e-01	8.92e-01	4.45e-01	2.25e-01



Evaluating how well SAI balanced 0 genes are linked to EA balanced genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
SAI balanced 0 Exclusive	EA balanced	0.51	0.73	0.75	0.76	0.77
EA balanced Exclusive	SAI balanced 0	0.57	1.06	1.32	1.05	2.82
SAI balanced 0 Exclusive	EA balanced Exclusive	0.51	0.44	0.35	0.44	0.19
EA balanced Exclusive	SAI balanced 0 Exclusive	0.57	1.06	1.47	0.98	2.39
SAI balanced 0 Exclusive	Overlap	0.59	1.16	1.22	1.08	1.00
EA balanced Exclusive	Overlap	0.53	-0.04	0.32	0.20	0.26
Overlap	Exclusives	0.53	0.12	0.11	0.40	1.16

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
SAI balanced 0 Exclusive	EA balanced	0.01	0.83	0.74	1.12	1.01
EA balanced Exclusive	SAI balanced 0	0.01	-0.11	1.01	0.47	1.57
SAI balanced 0 Exclusive	EA balanced Exclusive	0.01	0.45	0.14	1.00	0.12
EA balanced Exclusive	SAI balanced 0 Exclusive	0.01	0.36	1.36	0.40	0.74
SAI balanced 0 Exclusive	Overlap	0.00	0.44	2.56	1.70	1.65
EA balanced Exclusive	Overlap	0.00	-0.12	0.43	0.17	0.38
Overlap	Exclusives	0.01	0.70	0.62	0.79	0.97

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
SAI balanced 0 Exclusive	104	104	
EA balanced Exclusive	133	132	CHURC1-FNTB
Overlap	10	10