Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
SAI balanced 1 Exclusive	EA balanced	5.47e-01	9.12e-01	2.95e-01	3.45e-01
EA balanced Exclusive	SAI balanced 1	9.53e-01	8.21e-01	9.66e-01	3.70e-01
SAI balanced 1 Exclusive	EA balanced Exclusive	7.52e-01	9.16e-01	4.05e-01	3.93e-01
EA balanced Exclusive	SAI balanced 1 Exclusive	9.35e-01	8.88e-01	9.39e-01	1.98e-01
SAI balanced 1 Exclusive	Overlap	3.79e-01	4.57e-01	4.01e-01	2.01e-01
EA balanced Exclusive	Overlap	6.34e-01	9.26e-01	7.45e-01	7.60e-01
Overlap	Exclusives	1.07e-01	6.58e-01	5.25e-01	2.14e-01



Evaluating how well SAI balanced 1 genes are linked to EA balanced genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
SAI balanced 1 Exclusive	EA balanced	0.50	-0.12	-0.23	-0.04	-0.06
EA balanced Exclusive	SAI balanced 1	0.54	0.58	0.63	0.57	1.46
SAI balanced 1 Exclusive	EA balanced Exclusive	0.50	-0.14	-0.24	0.05	0.12
EA balanced Exclusive	SAI balanced 1 Exclusive	0.55	0.61	0.56	0.63	1.71
SAI balanced 1 Exclusive	Overlap	0.48	-0.25	0.01	-0.41	-0.22
EA balanced Exclusive	Overlap	0.53	-0.04	0.30	0.27	0.39
Overlap	Exclusives	0.52	-0.10	-0.25	0.05	0.90

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
SAI balanced 1 Exclusive	EA balanced	0.01	0.12	-0.20	0.15	-0.19
EA balanced Exclusive	SAI balanced 1	0.01	-0.27	0.35	-0.15	0.69
SAI balanced 1 Exclusive	EA balanced Exclusive	0.01	-0.16	-0.23	-0.00	-0.31
EA balanced Exclusive	SAI balanced 1 Exclusive	0.01	-0.25	0.48	-0.14	1.01
SAI balanced 1 Exclusive	Overlap	0.00	0.43	2.51	1.62	1.27
EA balanced Exclusive	Overlap	0.00	-0.17	-0.07	0.12	-0.05
Overlap	Exclusives	0.01	-0.00	0.13	0.38	0.53

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
SAI balanced 1 Exclusive	102	102	
EA balanced Exclusive	133	132	CHURC1-FNTB
Overlap	10	10