Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
SAI balanced 0	ismael	4.97e-01	6.25e-01	2.82e-01	1.30e-01
ismael	SAI balanced 0	5.95e-01	1.76e-01	1.15e-04	6.25e-02



Evaluating how well SAI balanced 0 genes are linked to ismael genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
SAI balanced 0	ismael	0.68	0.52	-0.19	0.43	2.12
ismael	SAI balanced 0	0.58	1.37	2.03	1.64	2.79

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
SAI balanced 0	ismael	0.01	11.60	19.09	8.81	36.71
ismael	SAI balanced 0	0.01	0.54	0.58	1.34	1.07

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
SAI balanced 0	114	114	
ismael	14	14