Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
SAI balanced 1	ismael	8.97e-01	7.55e-01	8.57e-01	2.14e-01
ismael	SAI balanced 1	3.21e-01	5.69e-01	1.07e-04	1.39e-01



Evaluating how well SAI balanced 1 genes are linked to ismael genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
SAI balanced 1	ismael	0.65	0.34	-0.66	0.02	1.98
ismael	SAI balanced 1	0.56	1.27	1.32	0.99	2.24

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
SAI balanced 1	ismael	0.00	3.04	9.19	3.34	1.79
ismael	SAI balanced 1	0.01	0.65	0.22	0.58	1.73

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
SAI balanced 1	112	112	
ismael	14	14