Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
SAI 6K	ismael	8.74e-01	5.22e-01	9.65e-01	2.94e-01
ismael	SAI 6K	3.47e-01	5.55e-01	1.77e-05	1.77e-01



Evaluating how well SAI 6K genes are linked to ismael genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
SAI 6K	ismael	0.63	-0.39	-1.33	-0.22	1.84
ismael	SAI 6K	0.54	1.17	1.24	1.02	1.67

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
SAI 6K	ismael	0.00	2.18	5.13	2.89	6.43
ismael	SAI 6K	0.01	0.04	0.02	0.14	0.49

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
SAI 6K	125	125	
ismael	14	14