Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
SAI EOAD	ismael	9.34e-01	7.60e-01	6.02e-01	1.16e-01
ismael	SAI EOAD	1.38e-01	3.74e-01	6.79e-04	2.20e-02



Evaluating how well SAI EOAD genes are linked to ismael genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
SAI EOAD	ismael	0.69	0.17	0.30	0.42	2.33
ismael	SAI EOAD	0.56	0.62	1.28	0.88	2.56

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
SAI EOAD	ismael	0.00	-0.24	-0.78	-0.06	0.57
ismael	SAI EOAD	0.01	0.38	0.35	0.12	0.51

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
SAI EOAD	97	97	
ismael	14	14