Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
ADC	ismael	2.82e-01	1.06e-01	1.35e-01	4.58e-02
ismael	ADC	3.68e-01	7.13e-02	3.19e-03	8.24e-03



Evaluating how well ADC genes are linked to ismael genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
ADC	ismael	0.71	0.42	0.66	0.84	2.58
ismael	ADC	0.58	1.86	1.81	1.65	2.31

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
ADC	ismael	0.00	1.41	6.29	3.56	10.15
ismael	ADC	0.01	0.80	0.76	1.44	0.84

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
ADC	97	96	MFRP
ismael	14	14