Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
LOAD	GWAS	1.44e-01	6.19e-02	6.06e-02	2.73e-03
GWAS	LOAD	3.98e-01	2.84e-01	1.05e-01	1.93e-01



Evaluating how well LOAD genes are linked to GWAS genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
LOAD	GWAS	0.66	0.61	1.66	0.79	2.98
GWAS	LOAD	0.55	1.49	1.29	1.11	1.77

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
LOAD	GWAS	0.00	0.15	1.65	0.34	1.41
GWAS	LOAD	0.01	1.08	1.04	0.56	0.21

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
LOAD	116	116	
GWAS	25	25