Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
ncSAI	Ismael	1.73e-01	5.22e-01	2.26e-01	1.29e-02
Ismael	ncSAI	6.96e-01	1.12e-02	6.04e-06	1.91e-02



Evaluating how well ncSAI genes are linked to Ismael genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
ncSAI	Ismael	0.72	0.75	0.79	0.63	2.78
Ismael	ncSAI	0.57	2.14	2.97	1.88	2.77

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
ncSAI	Ismael	0.00	0.09	7.51	1.62	7.29
Ismael	ncSAI	0.01	1.01	1.30	1.48	1.68

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
ncSAI	119	119	
Ismael	14	14