Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
only coding	Ismael	2.16e-01	1.24e-01	2.07e-01	6.38e-01
Ismael	only coding	1.79e-03	5.55e-01	8.97e-04	4.19e-01



Evaluating how well only coding genes are linked to Ismael genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
only coding	Ismael	0.51	-1.35	-2.69	-1.37	0.36
Ismael	only coding	0.50	-0.81	-0.45	-0.46	-0.09

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
only coding	Ismael	0.00	-0.61	-1.73	-0.89	-0.29
Ismael	only coding	0.00	-1.20	-1.06	-1.08	-0.77

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
only coding	77	77	
Ismael	14	14