Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
ncoding Exclusive	all variants	5.17e-01	6.91e-01	8.39e-02	5.23e-01
all variants Exclusive	ncoding	8.01e-01	6.02e-01	4.92e-01	2.76e-01
ncoding Exclusive	all variants Exclusive	8.66e-01	5.99e-01	3.43e-01	8.41e-01
all variants Exclusive	ncoding Exclusive	3.36e-01	2.89e-01	5.95e-01	1.26e-01
ncoding Exclusive	Overlap	6.97e-01	6.88e-01	2.64e-01	4.02e-01
all variants Exclusive	Overlap	3.55e-01	2.52e-01	1.29e-01	2.66e-02
Overlap	Exclusives	5.80e-01	9.20e-01	1.21e-01	6.63e-01



Evaluating how well ncoding genes are linked to all variants genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
ncoding Exclusive	all variants	0.53	-0.35	-0.31	-0.54	1.03
all variants Exclusive	ncoding	0.54	0.21	0.25	0.50	1.49
ncoding Exclusive	all variants Exclusive	0.48	-0.51	-1.02	-0.68	-0.47
all variants Exclusive	ncoding Exclusive	0.44	-0.90	-1.16	-0.80	-1.65
ncoding Exclusive	Overlap	0.54	-0.08	0.36	-0.20	1.23
all variants Exclusive	Overlap	0.58	1.12	1.06	1.38	2.52
Overlap	Exclusives	0.50	0.48	0.23	0.58	-0.09

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
ncoding Exclusive	all variants	0.01	-0.46	-0.14	-0.55	0.13
all variants Exclusive	ncoding	0.01	0.17	0.78	0.72	1.58
ncoding Exclusive	all variants Exclusive	0.00	-0.44	-0.88	-0.68	-0.40
all variants Exclusive	ncoding Exclusive	0.00	-0.67	-0.66	-0.32	-0.26
ncoding Exclusive	Overlap	0.00	-0.01	0.54	-0.21	0.19
all variants Exclusive	Overlap	0.01	1.57	1.59	1.45	0.59
Overlap	Exclusives	0.00	1.53	2.38	1.62	1.18

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
ncoding Exclusive	35	35	
all variants Exclusive	30	30	
Overlap	84	84