Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
no miss	ismael	4.92e-01	7.15e-01	6.88e-01	1.59e-01
ismael	no miss	4.70e-01	1.29e-01	3.46e-05	2.57e-02



Evaluating how well no miss genes are linked to ismael genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
no miss	ismael	0.69	0.89	0.04	0.30	2.06
ismael	no miss	0.57	1.81	1.80	1.39	2.47

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
no miss	ismael	0.00	5.96	6.11	1.75	5.85
ismael	no miss	0.01	1.39	0.69	0.96	1.93

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
no miss	123	123	
ismael	14	14