Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
all variants Exclusive	Lambert all	6.74e-06	4.03e-04	3.74e-06	3.73e-08
Lambert all Exclusive	all variants	3.08e-01	1.90e-03	5.72e-03	3.17e-04
all variants Exclusive	Lambert all Exclusive	4.28e-05	8.10e-04	1.16e-05	1.15e-07
Lambert all Exclusive	all variants Exclusive	4.44e-01	3.05e-03	9.40e-03	3.97e-04
all variants Exclusive	Overlap	2.10e-01	1.50e-01	1.86e-01	3.45e-02
Lambert all Exclusive	Overlap	4.36e-07	7.71e-02	4.36e-07	3.66e-05
Overlap	Exclusives	2.64e-04	3.79e-06	1.26e-28	1.22e-08



Evaluating how well all variants genes are linked to Lambert all genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
all variants Exclusive	Lambert all	0.67	3.44	4.48	2.44	5.50
Lambert all Exclusive	all variants	0.59	2.68	3.06	2.70	3.33
all variants Exclusive	Lambert all Exclusive	0.66	2.84	3.64	2.60	5.26
Lambert all Exclusive	all variants Exclusive	0.58	2.00	2.52	2.23	2.87
all variants Exclusive	Overlap	0.88	1.90	1.67	1.73	2.32
Lambert all Exclusive	Overlap	0.99	3.02	2.26	2.56	2.94
Overlap	Exclusives	0.64	4.62	6.29	2.55	7.12

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
all variants Exclusive	Lambert all	0.01	4.38	8.09	4.42	5.34
Lambert all Exclusive	all variants	0.01	5.69	3.16	8.87	8.58
all variants Exclusive	Lambert all Exclusive	0.01	4.60	7.67	4.97	9.84
Lambert all Exclusive	all variants Exclusive	0.01	2.31	4.29	3.30	2.50
all variants Exclusive	Overlap	0.00	1.61	1.14	1.54	-0.03
Lambert all Exclusive	Overlap	0.04	36.70	69.37	113.45	49.47
Overlap	Exclusives	0.04	27.70	41.77	15.15	43.89

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
all variants Exclusive	111	111	
Lambert all Exclusive	99	93	IGH;TNSF13;MS4A;APT8B4;TNSF12;AC074212.3
Overlap	3	3