Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
only coding Exclusive	lambert 1	3.08e-06	1.73e-06	6.84e-06	2.66e-08
lambert 1 Exclusive	only coding	4.19e-01	3.09e-02	2.47e-03	2.13e-02
only coding Exclusive	lambert 1 Exclusive	1.92e-06	4.69e-06	4.62e-05	1.83e-07
lambert 1 Exclusive	only coding Exclusive	5.86e-01	3.50e-02	7.00e-03	4.35e-02
only coding Exclusive	Overlap	3.96e-02	1.98e-02	1.98e-02	3.96e-02
lambert 1 Exclusive	Overlap	1.98e-02	1.98e-02	1.98e-02	1.98e-02
Overlap	Exclusives	2.09e-06	7.82e-06	4.00e-07	7.62e-07



Evaluating how well only coding genes are linked to lambert 1 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
only coding Exclusive	lambert 1	0.80	2.82	4.86	2.70	5.91
lambert 1 Exclusive	only coding	0.59	2.59	2.80	2.85	2.47
only coding Exclusive	lambert 1 Exclusive	0.79	3.07	5.17	2.90	7.16
lambert 1 Exclusive	only coding Exclusive	0.58	2.31	2.98	2.69	2.57
only coding Exclusive	Overlap	0.98	1.96	1.93	2.04	1.67
lambert 1 Exclusive	Overlap	0.99	2.12	1.51	2.10	1.77
Overlap	Exclusives	0.65	2.10	5.17	2.79	4.90

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
only coding Exclusive	lambert 1	0.01	5.53	6.78	4.64	9.71
lambert 1 Exclusive	only coding	0.01	1.49	4.27	6.20	1.00
only coding Exclusive	lambert 1 Exclusive	0.01	5.09	5.26	4.92	3.44
lambert 1 Exclusive	only coding Exclusive	0.01	2.32	2.32	3.83	3.40
only coding Exclusive	Overlap	0.00	0.53	7.71	11.87	4.54
lambert 1 Exclusive	Overlap	0.01	18.98	11.83	39.87	39.13
Overlap	Exclusives	0.01	5.96	9.39	7.36	7.78

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
only coding Exclusive	76	76	
lambert 1 Exclusive	30	29	MS4A
Overlap	1	1