Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
All variants Exclusive	Lambert 1	1.01e-04	8.58e-04	1.28e-04	1.81e-06
Lambert 1 Exclusive	All variants	6.70e-01	1.75e-01	1.94e-01	2.09e-02
All variants Exclusive	Lambert 1 Exclusive	1.58e-04	1.81e-03	1.88e-04	2.11e-05
Lambert 1 Exclusive	All variants Exclusive	7.33e-01	3.82e-01	1.38e-01	4.35e-02
All variants Exclusive	Overlap	1.98e-01	1.45e-01	2.41e-01	4.95e-02
Lambert 1 Exclusive	Overlap	4.36e-07	4.36e-07	4.36e-07	4.36e-06
Overlap	Exclusives	6.74e-04	5.12e-04	2.17e-17	8.28e-05



Evaluating how well All variants genes are linked to Lambert 1 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
All variants Exclusive	Lambert 1	0.77	2.63	4.23	2.47	4.94
Lambert 1 Exclusive	All variants	0.58	1.46	2.57	1.62	3.13
All variants Exclusive	Lambert 1 Exclusive	0.76	2.73	3.72	2.95	4.62
Lambert 1 Exclusive	All variants Exclusive	0.56	1.25	2.09	1.52	2.20
All variants Exclusive	Overlap	0.88	2.09	1.62	1.75	2.30
Lambert 1 Exclusive	Overlap	1.00	3.24	2.35	2.83	3.02
Overlap	Exclusives	0.62	4.50	4.05	2.70	4.83

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
All variants Exclusive	Lambert 1	0.01	4.40	7.31	2.56	5.78
Lambert 1 Exclusive	All variants	0.01	6.08	5.01	6.52	5.12
All variants Exclusive	Lambert 1 Exclusive	0.00	4.54	6.88	6.29	4.46
Lambert 1 Exclusive	All variants Exclusive	0.01	1.30	5.13	3.05	3.65
All variants Exclusive	Overlap	0.00	0.97	1.71	1.27	1.51
Lambert 1 Exclusive	Overlap	0.03	123.59	108.73	91.23	69.47
Overlap	Exclusives	0.04	54.66	53.36	24.90	31.77

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
All variants Exclusive	111	111	
Lambert 1 Exclusive	28	27	MS4A
Overlap	3	3