Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
Sigma_EUR_phenotypes2_ADC_age60_z_3_5	Isamel_14_AD	1.05e-02	2.68e-02	5.34e-03	9.35e-05
Isamel_14_AD	Sigma_EUR_phenotypes2_ADC_age60_z_3_5	5.30e-01	7.62e-01	4.97e-03	5.89e-01



Evaluating how well Sigma_EUR_phenotypes2_ADC_age60_z_3_5 genes are linked to Isamel_14_AD genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Sigma_EUR_phenotypes2_ADC_age60_z_3_5	Isamel_14_AD	0.83	2.35	3.41	2.11	4.31
Isamel_14_AD	Sigma_EUR_phenotypes2_ADC_age60_z_3_5	0.55	1.06	1.29	1.32	1.05

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Sigma_EUR_phenotypes2_ADC_age60_z_3_5	Isamel_14_AD	0.00	2.66	4.81	2.43	3.85
Isamel_14_AD	Sigma_EUR_phenotypes2_ADC_age60_z_3_5	0.00	2.63	1.88	2.78	2.49

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
Sigma_EUR_phenotypes2_ADC_age60_z_3_5	38	37	TMEM191C
Isamel_14_AD	14	14