Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
Sigma_EUR_phenotypes2_ADC_age60_z_3_5 Exclusive	ad_tier1_36	2.08e-01	7.81e-01	5.41e-01	9.75e-02
ad_tier1_36 Exclusive	Sigma_EUR_phenotypes2_ADC_age60_z_3_5	3.85e-01	5.01e-01	4.10e-01	5.46e-01
Sigma_EUR_phenotypes2_ADC_age60_z_3_5 Exclusive	ad_tier1_36 Exclusive	2.56e-01	8.26e-01	2.46e-01	2.08e-01
ad_tier1_36 Exclusive	Sigma_EUR_phenotypes2_ADC_age60_z_3_5 Exclusive	3.92e-01	9.75e-01	9.83e-01	9.79e-01
Sigma_EUR_phenotypes2_ADC_age60_z_3_5 Exclusive	Overlap	8.01e-01	4.50e-01	9.40e-01	2.10e-01
ad_tier1_36 Exclusive	Overlap	4.36e-07	4.36e-07	4.36e-07	1.74e-06
Overlap	Exclusives	3.88e-06	1.74e-07	9.55e-19	6.19e-08



Evaluating how well Sigma_EUR_phenotypes2_ADC_age60_z_3_5 genes are linked to ad_tier1_36 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Sigma_EUR_phenotypes2_ADC_age60_z_3_5 Exclusive	ad_tier1_36	0.59	-0.60	-0.04	0.06	1.59
ad_tier1_36 Exclusive	Sigma_EUR_phenotypes2_ADC_age60_z_3_5	0.52	0.30	0.25	0.45	0.47
Sigma_EUR_phenotypes2_ADC_age60_z_3_5 Exclusive	ad_tier1_36 Exclusive	0.57	-0.53	-0.07	-0.23	1.22
ad_tier1_36 Exclusive	Sigma_EUR_phenotypes2_ADC_age60_z_3_5 Exclusive	0.48	-0.25	-0.67	-0.07	-0.46
Sigma_EUR_phenotypes2_ADC_age60_z_3_5 Exclusive	Overlap	0.75	0.57	-0.16	0.53	1.70
ad_tier1_36 Exclusive	Overlap	1.00	2.47	2.45	2.46	2.62
Overlap	Exclusives	0.73	6.43	8.01	4.25	6.13

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Sigma_EUR_phenotypes2_ADC_age60_z_3_5 Exclusive	ad_tier1_36	0.00	-0.43	-0.45	-0.13	0.15
ad_tier1_36 Exclusive	Sigma_EUR_phenotypes2_ADC_age60_z_3_5	0.01	1.26	14.74	10.92	9.77
Sigma_EUR_phenotypes2_ADC_age60_z_3_5 Exclusive	ad_tier1_36 Exclusive	0.00	-0.42	-0.31	-0.27	0.18
ad_tier1_36 Exclusive	Sigma_EUR_phenotypes2_ADC_age60_z_3_5 Exclusive	0.00	-0.35	-0.52	-0.13	-0.38
Sigma_EUR_phenotypes2_ADC_age60_z_3_5 Exclusive	Overlap	0.00	-0.23	-0.87	-0.11	0.62
ad_tier1_36 Exclusive	Overlap	0.06	81.28	193.01	143.38	100.24
Overlap	Exclusives	0.07	74.40	133.11	72.12	124.39

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
Sigma_EUR_phenotypes2_ADC_age60_z_3_5 Exclusive	35	34	TMEM191C
ad_tier1_36 Exclusive	28	27	MS4A
Overlap	3	3