Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
Sigma_EUR_phenotypes2_ADC_age60_z_3 Exclusive	ad_tier1_36	1.54e-01	4.31e-01	3.16e-01	2.59e-01
ad_tier1_36 Exclusive	Sigma_EUR_phenotypes2_ADC_age60_z_3	2.73e-01	9.70e-01	4.71e-01	8.77e-01
Sigma_EUR_phenotypes2_ADC_age60_z_3 Exclusive	ad_tier1_36 Exclusive	1.08e-01	4.19e-01	2.34e-01	4.69e-01
ad_tier1_36 Exclusive	Sigma_EUR_phenotypes2_ADC_age60_z_3 Exclusive	1.63e-01	9.01e-01	9.94e-01	9.92e-01
Sigma_EUR_phenotypes2_ADC_age60_z_3 Exclusive	Overlap	6.48e-01	8.69e-01	6.39e-01	1.47e-01
ad_tier1_36 Exclusive	Overlap	9.14e-09	1.83e-09	2.74e-08	1.28e-07
Overlap	Exclusives	2.81e-03	1.84e-05	8.77e-16	2.66e-06



Evaluating how well Sigma_EUR_phenotypes2_ADC_age60_z_3 genes are linked to ad_tier1_36 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Sigma_EUR_phenotypes2_ADC_age60_z_3 Exclusive	ad_tier1_36	0.56	-0.72	-1.01	-0.47	1.04
ad_tier1_36 Exclusive	Sigma_EUR_phenotypes2_ADC_age60_z_3	0.52	0.17	-0.24	0.34	0.75
Sigma_EUR_phenotypes2_ADC_age60_z_3 Exclusive	ad_tier1_36 Exclusive	0.53	-0.97	-0.94	-0.77	0.76
ad_tier1_36 Exclusive	Sigma_EUR_phenotypes2_ADC_age60_z_3 Exclusive	0.50	-0.55	-0.80	-0.49	0.01
Sigma_EUR_phenotypes2_ADC_age60_z_3 Exclusive	Overlap	0.73	0.55	0.24	0.37	1.50
ad_tier1_36 Exclusive	Overlap	1.00	2.71	2.62	2.87	3.46
Overlap	Exclusives	0.64	4.87	5.24	3.78	5.14

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Sigma_EUR_phenotypes2_ADC_age60_z_3 Exclusive	ad_tier1_36	0.00	-0.40	-0.91	-0.38	0.25
ad_tier1_36 Exclusive	Sigma_EUR_phenotypes2_ADC_age60_z_3	0.01	1.68	1.59	1.80	1.35
Sigma_EUR_phenotypes2_ADC_age60_z_3 Exclusive	ad_tier1_36 Exclusive	0.00	-0.35	-0.72	-0.57	-0.03
ad_tier1_36 Exclusive	Sigma_EUR_phenotypes2_ADC_age60_z_3 Exclusive	0.00	-0.42	-0.37	-0.37	-0.33
Sigma_EUR_phenotypes2_ADC_age60_z_3 Exclusive	Overlap	0.00	-0.17	-1.77	-0.21	0.47
ad_tier1_36 Exclusive	Overlap	0.05	71.14	175.06	91.44	46.45
Overlap	Exclusives	0.03	35.43	15.28	28.32	24.07

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
Sigma_EUR_phenotypes2_ADC_age60_z_3 Exclusive	95	93	CHURC1-FNTB;TMEM191C
ad_tier1_36 Exclusive	27	26	MS4A
Overlap	4	4