Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
Sigma_EUR_phenotypes2_excluding_4cohort_age_60_z_3_5	Ismael_14_AD	2.82e-01	6.88e-01	5.18e-01	7.55e-03
Ismael_14_AD	Sigma_EUR_phenotypes2_excluding_4cohort_age_60_z_3_5	2.67e-03	8.75e-01	1.75e-03	7.95e-01



Evaluating how well Sigma_EUR_phenotypes2_excluding_4cohort_age_60_z_3_5 genes are linked to Ismael_14_AD genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Sigma_EUR_phenotypes2_excluding_4cohort_age_60_z_3_5	Ismael_14_AD	0.73	1.47	0.82	1.04	3.21
Ismael_14_AD	Sigma_EUR_phenotypes2_excluding_4cohort_age_60_z_3_5	0.50	-1.29	-0.36	-0.32	-0.18

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Sigma_EUR_phenotypes2_excluding_4cohort_age_60_z_3_5	Ismael_14_AD	0.00	0.41	-0.69	0.03	1.58
Ismael_14_AD	Sigma_EUR_phenotypes2_excluding_4cohort_age_60_z_3_5	0.01	-0.23	0.31	0.08	0.22

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
Sigma_EUR_phenotypes2_excluding_4cohort_age_60_z_3_5	91	91	
Ismael_14_AD	14	14