Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
Sigma_EUR_phenotypes2_excluding_4cohort_age_60_z_3 Exclusive	ad_tier1_36	3.45e-02	1.12e-01	7.82e-02	6.35e-01
ad_tier1_36 Exclusive	Sigma_EUR_phenotypes2_excluding_4cohort_age_60_z_3	1.74e-01	8.42e-01	9.57e-01	8.15e-01
Sigma_EUR_phenotypes2_excluding_4cohort_age_60_z_3 Exclusive	ad_tier1_36 Exclusive	4.85e-02	9.68e-02	4.75e-02	7.46e-01
ad_tier1_36 Exclusive	Sigma_EUR_phenotypes2_excluding_4cohort_age_60_z_3 Exclusive	1.57e-01	7.20e-01	7.92e-01	6.92e-01
Sigma_EUR_phenotypes2_excluding_4cohort_age_60_z_3 Exclusive	Overlap	9.43e-01	8.87e-01	9.48e-01	8.22e-01
ad_tier1_36 Exclusive	Overlap	1.83e-09	1.83e-09	1.83e-09	2.74e-08
Overlap	Exclusives	4.22e-02	3.41e-02	1.07e-12	9.16e-03



Evaluating how well Sigma_EUR_phenotypes2_excluding_4cohort_age_60_z_3 genes are linked to ad_tier1_36 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Sigma_EUR_phenotypes2_excluding_4cohort_age_60_z_3 Exclusive	ad_tier1_36	0.53	-1.42	-1.66	-1.19	0.69
ad_tier1_36 Exclusive	Sigma_EUR_phenotypes2_excluding_4cohort_age_60_z_3	0.51	-0.31	-0.39	0.07	0.63
Sigma_EUR_phenotypes2_excluding_4cohort_age_60_z_3 Exclusive	ad_tier1_36 Exclusive	0.51	-1.27	-2.17	-1.21	0.17
ad_tier1_36 Exclusive	Sigma_EUR_phenotypes2_excluding_4cohort_age_60_z_3 Exclusive	0.50	-0.73	-0.73	-0.29	0.05
Sigma_EUR_phenotypes2_excluding_4cohort_age_60_z_3 Exclusive	Overlap	0.62	-0.58	-0.51	-0.43	0.87
ad_tier1_36 Exclusive	Overlap	1.00	2.85	2.58	2.80	3.13
Overlap	Exclusives	0.56	3.56	2.73	2.42	2.94

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Sigma_EUR_phenotypes2_excluding_4cohort_age_60_z_3 Exclusive	ad_tier1_36	0.00	-0.91	-1.26	-0.83	-0.26
ad_tier1_36 Exclusive	Sigma_EUR_phenotypes2_excluding_4cohort_age_60_z_3	0.01	0.99	1.03	0.77	0.82
Sigma_EUR_phenotypes2_excluding_4cohort_age_60_z_3 Exclusive	ad_tier1_36 Exclusive	0.00	-0.98	-1.65	-0.85	-0.41
ad_tier1_36 Exclusive	Sigma_EUR_phenotypes2_excluding_4cohort_age_60_z_3 Exclusive	0.01	-1.10	-0.83	-0.78	-0.62
Sigma_EUR_phenotypes2_excluding_4cohort_age_60_z_3 Exclusive	Overlap	0.00	-0.70	-0.50	-0.52	-0.05
ad_tier1_36 Exclusive	Overlap	0.05	168.63	135.39	154.92	11.76
Overlap	Exclusives	0.03	18.59	23.78	14.29	15.08

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
Sigma_EUR_phenotypes2_excluding_4cohort_age_60_z_3 Exclusive	166	163	FIGNL2;AC187653.1;CHURC1-FNTB
ad_tier1_36 Exclusive	27	26	MS4A
Overlap	4	4