Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
Sigma_EUR_phenotypes2_excluding_4cohort_age_60_z_3	Ismael_14_AD	8.06e-01	5.22e-01	8.78e-01	3.93e-02
Ismael_14_AD	Sigma_EUR_phenotypes2_excluding_4cohort_age_60_z_3	2.17e-03	8.67e-01	4.15e-07	5.77e-01



Evaluating how well Sigma_EUR_phenotypes2_excluding_4cohort_age_60_z_3 genes are linked to Ismael_14_AD genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Sigma_EUR_phenotypes2_excluding_4cohort_age_60_z_3	Ismael_14_AD	0.67	0.04	-0.18	-0.01	2.32
Ismael_14_AD	Sigma_EUR_phenotypes2_excluding_4cohort_age_60_z_3	0.51	-0.18	-0.57	0.09	0.62

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Sigma_EUR_phenotypes2_excluding_4cohort_age_60_z_3	Ismael_14_AD	0.00	-0.46	-0.68	-0.36	1.51
Ismael_14_AD	Sigma_EUR_phenotypes2_excluding_4cohort_age_60_z_3	0.01	-0.29	-0.55	-0.09	-0.05

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
Sigma_EUR_phenotypes2_excluding_4cohort_age_60_z_3	170	167	CHURC1-FNTB;AC187653.1;FIGNL2
Ismael_14_AD	14	14