Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
Sigma_EUR_phenotypes2_old_ROS_MAP_z_3_5	ad_tier1_36	2.30e-01	1.03e-01	1.89e-01	4.90e-03
ad_tier1_36	Sigma_EUR_phenotypes2_old_ROS_MAP_z_3_5	7.71e-01	3.46e-01	2.44e-01	3.96e-01



Evaluating how well Sigma_EUR_phenotypes2_old_ROS_MAP_z_3_5 genes are linked to ad_tier1_36 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Sigma_EUR_phenotypes2_old_ROS_MAP_z_3_5	ad_tier1_36	0.67	1.10	2.00	1.12	3.33
ad_tier1_36	Sigma_EUR_phenotypes2_old_ROS_MAP_z_3_5	0.58	2.26	1.43	1.55	1.10

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Sigma_EUR_phenotypes2_old_ROS_MAP_z_3_5	ad_tier1_36	0.00	0.57	1.04	0.25	0.82
ad_tier1_36	Sigma_EUR_phenotypes2_old_ROS_MAP_z_3_5	0.00	1.08	0.44	0.11	-0.03

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
Sigma_EUR_phenotypes2_old_ROS_MAP_z_3_5	21	21	
ad_tier1_36	31	30	MS4A