Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
Sigma_EUR_phenotypes2_old_ROS_MAP_z_3_5	Ismael_14_AD	2.16e-01	2.95e-02	2.53e-01	2.51e-02
Ismael_14_AD	Sigma_EUR_phenotypes2_old_ROS_MAP_z_3_5	1.81e-01	2.42e-01	4.73e-03	1.30e-01



Evaluating how well Sigma_EUR_phenotypes2_old_ROS_MAP_z_3_5 genes are linked to Ismael_14_AD genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Sigma_EUR_phenotypes2_old_ROS_MAP_z_3_5	Ismael_14_AD	0.70	0.39	0.72	0.32	2.60
Ismael_14_AD	Sigma_EUR_phenotypes2_old_ROS_MAP_z_3_5	0.60	3.20	1.71	2.02	1.50

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Sigma_EUR_phenotypes2_old_ROS_MAP_z_3_5	Ismael_14_AD	0.00	0.16	0.45	-0.05	-0.03
Ismael_14_AD	Sigma_EUR_phenotypes2_old_ROS_MAP_z_3_5	0.00	1.22	0.48	-0.05	0.19

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
Sigma_EUR_phenotypes2_old_ROS_MAP_z_3_5	21	21	
Ismael_14_AD	14	14