Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
B_positive	B_negative	2.97e-01	6.73e-01	6.26e-02	4.54e-02
B_negative	B_positive	4.61e-01	8.83e-01	1.18e-01	2.25e-03



Evaluating how well B_positive genes are linked to B_negative genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
B_positive	B_negative	0.60	-0.11	0.14	0.70	2.17
B_negative	B_positive	0.66	0.20	0.59	0.69	3.65

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
B_positive	B_negative	0.00	-0.11	0.21	1.07	1.47
B_negative	B_positive	0.00	0.03	0.64	1.07	2.91

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
B_positive	55	53	USP9Y;NLGN4Y
B_negative	44	41	AC100868.1;UGT2A1;AC003002.1