Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
C positive	C negative	8.78e-01	9.64e-01	1.67e-01	5.83e-02
C negative	C positive	8.88e-01	8.23e-01	3.66e-01	1.55e-02



Evaluating how well C positive genes are linked to C negative genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
C positive	C negative	0.56	0.21	-0.05	0.23	1.20
C negative	C positive	0.58	0.15	0.22	0.21	2.29

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
C positive	C negative	0.00	-0.09	-0.24	-0.16	-0.03
C negative	C positive	0.00	-0.39	-0.44	-0.30	0.91

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
C positive	64	61	NLGN4Y;6-Mar;USP9Y
C negative	56	54	AC100868.1;AC003002.1