Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
A positive	A negative	1.73e-01	1.32e-01	2.29e-02	9.75e-02
A negative	A positive	8.42e-02	8.42e-02	1.56e-02	2.47e-03



Evaluating how well A positive genes are linked to A negative genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
A positive	A negative	0.63	0.95	1.61	0.90	2.16
A negative	A positive	0.78	3.04	3.03	2.74	3.62

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
A positive	A negative	0.00	2.51	2.24	0.53	0.18
A negative	A positive	0.00	2.03	2.29	2.27	2.84

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
A positive	14	14	
A negative	27	25	AC003002.1;UGT2A1