Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
A positive Exclusive	C positive	7.30e-03	7.23e-02	1.83e-08	1.13e-03
C positive Exclusive	A positive	1.41e-02	2.32e-03	6.38e-05	9.20e-06
A positive Exclusive	C positive Exclusive	2.31e-02	9.29e-02	3.31e-08	2.37e-03
C positive Exclusive	A positive Exclusive	6.01e-02	1.47e-02	2.22e-03	6.03e-04
A positive Exclusive	Overlap	8.27e-01	7.55e-01	1.86e-01	2.63e-01
C positive Exclusive	Overlap	1.43e-01	2.45e-02	1.36e-02	7.20e-03
Overlap	Exclusives	3.02e-03	1.83e-03	1.85e-09	1.36e-10



Evaluating how well A positive genes are linked to C positive genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
A positive Exclusive	C positive	0.64	1.28	1.02	0.88	3.58
C positive Exclusive	A positive	0.80	2.59	3.30	2.99	4.00
A positive Exclusive	C positive Exclusive	0.64	0.97	0.84	1.01	3.69
C positive Exclusive	A positive Exclusive	0.84	1.71	2.24	2.13	3.52
A positive Exclusive	Overlap	0.59	0.46	0.75	0.11	0.84
C positive Exclusive	Overlap	0.76	1.83	2.34	1.98	2.77
Overlap	Exclusives	0.72	4.35	4.24	3.08	6.21

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
A positive Exclusive	C positive	0.01	1.63	1.29	1.43	2.48
C positive Exclusive	A positive	0.00	3.32	6.55	0.15	3.73
A positive Exclusive	C positive Exclusive	0.00	1.53	1.46	1.62	2.78
C positive Exclusive	A positive Exclusive	0.00	0.81	2.56	2.01	1.79
A positive Exclusive	Overlap	0.00	-0.09	0.08	-0.05	0.13
C positive Exclusive	Overlap	0.00	2.18	7.53	0.35	3.48
Overlap	Exclusives	0.01	3.57	3.44	3.14	5.87

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
A positive Exclusive	7	7	
C positive Exclusive	57	55	USP9Y;NLGN4Y
Overlap	7	7