Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
B positive Exclusive	C positive	9.18e-05	1.19e-04	2.27e-10	4.95e-07
C positive Exclusive	B positive	2.11e-06	4.18e-09	1.11e-14	4.55e-17
B positive Exclusive	C positive Exclusive	7.67e-02	9.94e-02	4.96e-06	1.44e-03
C positive Exclusive	B positive Exclusive	1.45e-04	1.60e-05	1.31e-09	8.08e-13
B positive Exclusive	Overlap	8.88e-05	3.10e-05	1.14e-08	8.59e-07
C positive Exclusive	Overlap	2.32e-03	2.44e-04	8.77e-06	6.68e-05
Overlap	Exclusives	4.60e-06	3.32e-05	3.18e-09	1.21e-09



Evaluating how well B positive genes are linked to C positive genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
B positive Exclusive	C positive	0.71	3.72	4.62	3.69	6.16
C positive Exclusive	B positive	0.80	4.48	6.36	5.14	7.89
B positive Exclusive	C positive Exclusive	0.67	2.88	2.66	2.97	4.56
C positive Exclusive	B positive Exclusive	0.81	3.64	4.61	3.98	7.17
B positive Exclusive	Overlap	0.77	3.30	4.04	3.46	4.61
C positive Exclusive	Overlap	0.79	3.78	4.43	3.73	4.18
Overlap	Exclusives	0.75	5.08	5.93	4.41	7.59

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
B positive Exclusive	C positive	0.01	11.00	13.47	13.67	14.10
C positive Exclusive	B positive	0.01	5.45	9.48	7.04	11.05
B positive Exclusive	C positive Exclusive	0.00	2.27	2.86	4.78	4.06
C positive Exclusive	B positive Exclusive	0.01	3.46	4.42	4.69	4.54
B positive Exclusive	Overlap	0.01	21.11	37.03	6.27	31.91
C positive Exclusive	Overlap	0.00	5.59	9.99	7.68	3.31
Overlap	Exclusives	0.01	16.34	11.44	13.67	16.99

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
B positive Exclusive	33	33	
C positive Exclusive	42	41	6-Mar
Overlap	22	20	NLGN4Y;USP9Y