Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
A Exclusive	B	4.46e-02	3.85e-01	4.63e-05	2.96e-05
B Exclusive	A	2.70e-01	2.36e-01	1.40e-03	1.08e-03
A Exclusive	B Exclusive	6.28e-02	4.43e-01	6.66e-04	3.88e-05
B Exclusive	A Exclusive	9.16e-01	7.07e-01	9.65e-02	1.04e-01
A Exclusive	Overlap	5.45e-01	9.96e-01	1.44e-01	1.78e-01
B Exclusive	Overlap	1.39e-01	1.50e-01	7.32e-03	1.45e-02
Overlap	Exclusives	3.99e-03	7.77e-03	7.79e-06	1.60e-08



Evaluating how well A genes are linked to B genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
A Exclusive	B	0.64	1.27	0.80	0.70	4.40
B Exclusive	A	0.66	1.29	1.91	1.74	3.26
A Exclusive	B Exclusive	0.65	0.94	0.84	0.40	4.59
B Exclusive	A Exclusive	0.65	1.03	1.09	1.42	2.15
A Exclusive	Overlap	0.62	0.69	0.17	0.47	2.03
B Exclusive	Overlap	0.67	1.13	1.52	1.24	2.40
Overlap	Exclusives	0.69	2.59	3.97	2.19	5.81

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
A Exclusive	B	0.01	1.81	0.81	0.71	3.29
B Exclusive	A	0.01	5.48	11.35	4.88	11.64
A Exclusive	B Exclusive	0.01	1.29	0.95	0.89	2.89
B Exclusive	A Exclusive	0.00	0.31	1.14	1.77	1.79
A Exclusive	Overlap	0.00	0.58	-0.13	0.20	0.39
B Exclusive	Overlap	0.01	11.01	15.45	10.94	14.34
Overlap	Exclusives	0.01	2.40	4.55	2.97	5.65

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
A Exclusive	16	16	
B Exclusive	79	76	NLGN4Y;USP9Y;AC100868.1
Overlap	20	18	UGT2A1;AC003002.1