Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
B Exclusive	C	5.65e-03	1.91e-03	2.03e-12	8.50e-08
C Exclusive	B	1.26e-03	1.07e-03	1.51e-07	9.93e-12
B Exclusive	C Exclusive	8.58e-02	6.32e-02	8.23e-07	1.34e-03
C Exclusive	B Exclusive	3.59e-03	7.26e-04	1.21e-06	5.53e-10
B Exclusive	Overlap	1.00e-02	3.15e-03	3.49e-08	1.32e-06
C Exclusive	Overlap	8.30e-02	2.49e-02	3.97e-03	5.69e-05
Overlap	Exclusives	2.51e-04	9.78e-04	2.54e-09	1.70e-07



Evaluating how well B genes are linked to C genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
B Exclusive	C	0.66	3.15	4.05	3.91	5.64
C Exclusive	B	0.71	2.90	5.23	3.81	7.17
B Exclusive	C Exclusive	0.63	2.86	2.31	2.51	4.42
C Exclusive	B Exclusive	0.72	2.90	3.27	2.80	5.21
B Exclusive	Overlap	0.72	2.94	3.77	3.45	5.13
C Exclusive	Overlap	0.70	3.10	3.43	3.51	4.73
Overlap	Exclusives	0.67	3.07	4.02	3.82	7.27

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
B Exclusive	C	0.01	7.90	8.74	7.62	4.21
C Exclusive	B	0.01	2.21	4.15	4.37	9.43
B Exclusive	C Exclusive	0.01	2.57	1.47	2.12	2.41
C Exclusive	B Exclusive	0.01	2.16	2.37	2.31	1.23
B Exclusive	Overlap	0.01	12.68	21.74	21.27	3.10
C Exclusive	Overlap	0.00	3.19	2.95	3.68	0.59
Overlap	Exclusives	0.01	5.97	7.59	6.26	12.91

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
B Exclusive	56	55	UGT2A1
C Exclusive	77	76	6-Mar
Overlap	43	39	AC003002.1;NLGN4Y;AC100868.1;USP9Y