Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
A Exclusive	C	3.46e-02	1.68e-01	9.41e-05	3.31e-04
C Exclusive	A	4.48e-02	4.48e-02	5.92e-04	2.07e-04
A Exclusive	C Exclusive	8.85e-02	4.29e-01	4.36e-04	1.18e-03
C Exclusive	A Exclusive	2.05e-01	4.14e-01	1.82e-02	1.79e-02
A Exclusive	Overlap	4.34e-02	1.90e-01	3.38e-02	3.15e-02
C Exclusive	Overlap	1.95e-01	1.23e-01	4.05e-02	2.25e-02
Overlap	Exclusives	9.76e-02	7.55e-03	1.40e-09	4.60e-09



Evaluating how well A genes are linked to C genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
A Exclusive	C	0.63	2.13	2.34	2.23	4.50
C Exclusive	A	0.67	2.16	2.26	2.06	3.41
A Exclusive	C Exclusive	0.62	1.98	1.68	1.53	4.24
C Exclusive	A Exclusive	0.66	1.74	1.53	1.54	2.93
A Exclusive	Overlap	0.71	1.96	2.13	2.05	2.23
C Exclusive	Overlap	0.70	1.54	1.80	1.21	2.03
Overlap	Exclusives	0.64	2.37	3.32	2.20	6.51

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
A Exclusive	C	0.01	2.02	1.97	0.93	1.22
C Exclusive	A	0.01	3.40	3.93	0.65	9.27
A Exclusive	C Exclusive	0.01	1.68	1.64	0.77	1.12
C Exclusive	A Exclusive	0.00	5.41	4.25	6.78	3.13
A Exclusive	Overlap	0.00	2.03	1.45	0.64	1.72
C Exclusive	Overlap	0.00	0.36	1.51	-0.11	1.69
Overlap	Exclusives	0.01	2.27	2.59	2.53	2.79

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
A Exclusive	24	23	UGT2A1
C Exclusive	108	104	NLGN4Y;6-Mar;AC100868.1;USP9Y
Overlap	12	11	AC003002.1