Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
Sigma_EUR_phenotypes2_excluding_old_samples_86_z_3 Exclusive	ad_gs_tier1	9.93e-01	7.78e-01	9.99e-01	2.10e-01
ad_gs_tier1 Exclusive	Sigma_EUR_phenotypes2_excluding_old_samples_86_z_3	2.70e-01	4.77e-01	3.62e-01	1.33e-01
Sigma_EUR_phenotypes2_excluding_old_samples_86_z_3 Exclusive	ad_gs_tier1 Exclusive	9.95e-01	8.23e-01	9.85e-01	7.78e-01
ad_gs_tier1 Exclusive	Sigma_EUR_phenotypes2_excluding_old_samples_86_z_3 Exclusive	2.53e-01	5.80e-01	2.88e-01	3.53e-01
Sigma_EUR_phenotypes2_excluding_old_samples_86_z_3 Exclusive	Overlap	4.54e-01	8.69e-01	8.15e-01	8.38e-02
ad_gs_tier1 Exclusive	Overlap	1.83e-09	1.83e-09	1.83e-09	1.83e-06
Overlap	Exclusives	4.23e-03	2.40e-03	2.92e-11	1.52e-03



Evaluating how well Sigma_EUR_phenotypes2_excluding_old_samples_86_z_3 genes are linked to ad_gs_tier1 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Sigma_EUR_phenotypes2_excluding_old_samples_86_z_3 Exclusive	ad_gs_tier1	0.58	0.12	-0.78	-0.18	1.77
ad_gs_tier1 Exclusive	Sigma_EUR_phenotypes2_excluding_old_samples_86_z_3	0.52	0.14	0.16	0.31	1.13
Sigma_EUR_phenotypes2_excluding_old_samples_86_z_3 Exclusive	ad_gs_tier1 Exclusive	0.56	-0.20	-0.96	-0.40	0.68
ad_gs_tier1 Exclusive	Sigma_EUR_phenotypes2_excluding_old_samples_86_z_3 Exclusive	0.51	-0.40	-0.19	-0.09	0.40
Sigma_EUR_phenotypes2_excluding_old_samples_86_z_3 Exclusive	Overlap	0.75	0.92	0.33	0.34	1.76
ad_gs_tier1 Exclusive	Overlap	1.00	2.95	3.01	2.52	3.58
Overlap	Exclusives	0.58	5.25	3.29	2.49	3.67

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Sigma_EUR_phenotypes2_excluding_old_samples_86_z_3 Exclusive	ad_gs_tier1	0.00	-0.23	-0.85	-0.41	0.27
ad_gs_tier1 Exclusive	Sigma_EUR_phenotypes2_excluding_old_samples_86_z_3	0.01	2.66	2.93	1.95	1.06
Sigma_EUR_phenotypes2_excluding_old_samples_86_z_3 Exclusive	ad_gs_tier1 Exclusive	0.00	-0.44	-1.00	-0.30	-0.15
ad_gs_tier1 Exclusive	Sigma_EUR_phenotypes2_excluding_old_samples_86_z_3 Exclusive	0.01	-0.60	-0.37	-0.34	-0.23
Sigma_EUR_phenotypes2_excluding_old_samples_86_z_3 Exclusive	Overlap	0.00	-0.37	-0.46	-0.45	0.29
ad_gs_tier1 Exclusive	Overlap	0.05	147.82	206.34	170.62	30.31
Overlap	Exclusives	0.03	17.73	36.66	20.25	15.09

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
Sigma_EUR_phenotypes2_excluding_old_samples_86_z_3 Exclusive	139	138	CHURC1-FNTB
ad_gs_tier1 Exclusive	27	26	MS4A
Overlap	4	4