Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
Sigma_EUR_phenotypes2_young_excluding_OLD_z3 Exclusive	tier1_31	9.67e-01	8.98e-01	7.60e-01	8.34e-02
tier1_31 Exclusive	Sigma_EUR_phenotypes2_young_excluding_OLD_z3	2.57e-01	3.51e-01	1.55e-01	3.75e-01
Sigma_EUR_phenotypes2_young_excluding_OLD_z3 Exclusive	tier1_31 Exclusive	6.88e-01	5.95e-01	6.94e-01	2.34e-01
tier1_31 Exclusive	Sigma_EUR_phenotypes2_young_excluding_OLD_z3 Exclusive	2.53e-01	7.64e-01	3.96e-01	6.96e-01
Sigma_EUR_phenotypes2_young_excluding_OLD_z3 Exclusive	Overlap	4.70e-01	3.99e-01	6.13e-01	1.01e-01
tier1_31 Exclusive	Overlap	1.83e-09	1.83e-09	2.74e-08	6.40e-08
Overlap	Exclusives	4.46e-03	1.59e-03	5.61e-10	1.65e-03



Evaluating how well Sigma_EUR_phenotypes2_young_excluding_OLD_z3 genes are linked to tier1_31 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Sigma_EUR_phenotypes2_young_excluding_OLD_z3 Exclusive	tier1_31	0.60	0.05	-0.07	-0.22	1.93
tier1_31 Exclusive	Sigma_EUR_phenotypes2_young_excluding_OLD_z3	0.53	0.69	0.75	1.02	1.19
Sigma_EUR_phenotypes2_young_excluding_OLD_z3 Exclusive	tier1_31 Exclusive	0.57	-0.02	-0.30	-0.06	1.05
tier1_31 Exclusive	Sigma_EUR_phenotypes2_young_excluding_OLD_z3 Exclusive	0.52	0.29	-0.17	0.52	0.70
Sigma_EUR_phenotypes2_young_excluding_OLD_z3 Exclusive	Overlap	0.76	1.29	1.12	0.87	1.90
tier1_31 Exclusive	Overlap	1.00	3.14	2.99	2.56	3.21
Overlap	Exclusives	0.58	4.19	3.48	2.91	3.54

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Sigma_EUR_phenotypes2_young_excluding_OLD_z3 Exclusive	tier1_31	0.00	-0.21	-0.25	-0.32	0.60
tier1_31 Exclusive	Sigma_EUR_phenotypes2_young_excluding_OLD_z3	0.01	2.55	3.73	3.00	1.45
Sigma_EUR_phenotypes2_young_excluding_OLD_z3 Exclusive	tier1_31 Exclusive	0.00	-0.27	-0.47	-0.25	0.03
tier1_31 Exclusive	Sigma_EUR_phenotypes2_young_excluding_OLD_z3 Exclusive	0.01	-0.02	-0.16	-0.07	0.03
Sigma_EUR_phenotypes2_young_excluding_OLD_z3 Exclusive	Overlap	0.00	0.33	1.48	-0.03	0.29
tier1_31 Exclusive	Overlap	0.05	116.33	151.46	116.48	202.01
Overlap	Exclusives	0.03	16.89	31.64	17.49	24.13

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
Sigma_EUR_phenotypes2_young_excluding_OLD_z3 Exclusive	152	151	CHURC1-FNTB
tier1_31 Exclusive	27	26	MS4A
Overlap	4	4