Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
Sigma_EUR_phenotypes2_young_excluding_OLD_z3_5 Exclusive	TIER1_GS	4.31e-01	2.85e-01	5.44e-01	2.02e-02
TIER1_GS Exclusive	Sigma_EUR_phenotypes2_young_excluding_OLD_z3_5	3.99e-01	8.36e-01	6.58e-01	7.21e-01
Sigma_EUR_phenotypes2_young_excluding_OLD_z3_5 Exclusive	TIER1_GS Exclusive	5.21e-01	5.21e-01	7.39e-01	3.00e-02
TIER1_GS Exclusive	Sigma_EUR_phenotypes2_young_excluding_OLD_z3_5 Exclusive	3.27e-01	9.22e-01	8.85e-01	9.30e-01
Sigma_EUR_phenotypes2_young_excluding_OLD_z3_5 Exclusive	Overlap	6.22e-02	1.65e-01	8.78e-02	1.34e-02
TIER1_GS Exclusive	Overlap	4.36e-07	4.36e-07	4.36e-07	8.71e-06
Overlap	Exclusives	3.13e-06	1.16e-05	3.60e-08	5.59e-06



Evaluating how well Sigma_EUR_phenotypes2_young_excluding_OLD_z3_5 genes are linked to TIER1_GS genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Sigma_EUR_phenotypes2_young_excluding_OLD_z3_5 Exclusive	TIER1_GS	0.64	0.76	1.56	0.60	2.36
TIER1_GS Exclusive	Sigma_EUR_phenotypes2_young_excluding_OLD_z3_5	0.53	0.64	0.30	0.63	1.06
Sigma_EUR_phenotypes2_young_excluding_OLD_z3_5 Exclusive	TIER1_GS Exclusive	0.62	0.58	1.10	0.41	2.22
TIER1_GS Exclusive	Sigma_EUR_phenotypes2_young_excluding_OLD_z3_5 Exclusive	0.51	-0.12	-0.22	-0.06	0.43
Sigma_EUR_phenotypes2_young_excluding_OLD_z3_5 Exclusive	Overlap	0.81	1.39	1.96	1.25	1.79
TIER1_GS Exclusive	Overlap	1.00	3.02	3.15	2.43	3.41
Overlap	Exclusives	0.65	4.91	4.17	3.02	5.05

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Sigma_EUR_phenotypes2_young_excluding_OLD_z3_5 Exclusive	TIER1_GS	0.00	-0.04	0.20	-0.14	1.09
TIER1_GS Exclusive	Sigma_EUR_phenotypes2_young_excluding_OLD_z3_5	0.01	6.30	6.28	8.23	1.39
Sigma_EUR_phenotypes2_young_excluding_OLD_z3_5 Exclusive	TIER1_GS Exclusive	0.00	-0.21	-0.14	-0.16	-0.07
TIER1_GS Exclusive	Sigma_EUR_phenotypes2_young_excluding_OLD_z3_5 Exclusive	0.00	-0.17	-0.05	-0.09	0.10
Sigma_EUR_phenotypes2_young_excluding_OLD_z3_5 Exclusive	Overlap	0.00	0.47	0.48	0.16	0.68
TIER1_GS Exclusive	Overlap	0.04	92.81	189.85	73.64	121.08
Overlap	Exclusives	0.03	65.03	54.25	40.88	51.95

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
Sigma_EUR_phenotypes2_young_excluding_OLD_z3_5 Exclusive	58	57	CHURC1-FNTB
TIER1_GS Exclusive	28	27	MS4A
Overlap	3	3