Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
Sigma_EUR_phenotypes2_young_excluding_OLD_z3_5 Exclusive	Ismael_14_AD	2.32e-03	1.56e-02	6.20e-04	4.29e-06
Ismael_14_AD Exclusive	Sigma_EUR_phenotypes2_young_excluding_OLD_z3_5	1.30e-01	6.89e-01	1.55e-03	7.46e-01
Sigma_EUR_phenotypes2_young_excluding_OLD_z3_5 Exclusive	Ismael_14_AD Exclusive	1.22e-02	3.43e-02	1.87e-03	9.32e-06
Ismael_14_AD Exclusive	Sigma_EUR_phenotypes2_young_excluding_OLD_z3_5 Exclusive	1.08e-01	6.28e-01	1.75e-03	8.17e-01
Sigma_EUR_phenotypes2_young_excluding_OLD_z3_5 Exclusive	Overlap	1.98e-01	1.78e-01	1.78e-01	2.97e-01
Ismael_14_AD Exclusive	Overlap	1.98e-02	1.98e-02	1.98e-02	1.98e-02
Overlap	Exclusives	3.00e-03	1.14e-03	2.10e-03	1.85e-03



Evaluating how well Sigma_EUR_phenotypes2_young_excluding_OLD_z3_5 genes are linked to Ismael_14_AD genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Sigma_EUR_phenotypes2_young_excluding_OLD_z3_5 Exclusive	Ismael_14_AD	0.84	2.38	3.44	2.53	4.42
Ismael_14_AD Exclusive	Sigma_EUR_phenotypes2_young_excluding_OLD_z3_5	0.53	-0.07	0.19	0.61	0.66
Sigma_EUR_phenotypes2_young_excluding_OLD_z3_5 Exclusive	Ismael_14_AD Exclusive	0.83	2.04	2.82	2.07	4.51
Ismael_14_AD Exclusive	Sigma_EUR_phenotypes2_young_excluding_OLD_z3_5 Exclusive	0.52	-0.23	-0.12	0.24	0.61
Sigma_EUR_phenotypes2_young_excluding_OLD_z3_5 Exclusive	Overlap	0.88	1.54	1.71	1.45	1.11
Ismael_14_AD Exclusive	Overlap	1.00	7.54	1.58	2.40	1.69
Overlap	Exclusives	0.55	-0.00	-0.13	0.11	1.25

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Sigma_EUR_phenotypes2_young_excluding_OLD_z3_5 Exclusive	Ismael_14_AD	0.00	1.18	1.70	2.00	3.30
Ismael_14_AD Exclusive	Sigma_EUR_phenotypes2_young_excluding_OLD_z3_5	0.01	10.27	12.39	16.23	3.30
Sigma_EUR_phenotypes2_young_excluding_OLD_z3_5 Exclusive	Ismael_14_AD Exclusive	0.00	1.04	1.54	0.64	6.34
Ismael_14_AD Exclusive	Sigma_EUR_phenotypes2_young_excluding_OLD_z3_5 Exclusive	0.00	2.13	1.60	2.79	1.74
Sigma_EUR_phenotypes2_young_excluding_OLD_z3_5 Exclusive	Overlap	0.00	0.10	1.87	0.00	0.04
Ismael_14_AD Exclusive	Overlap	0.25	23045.96	492.66	197.62	296.55
Overlap	Exclusives	0.02	19.27	30.09	20.80	10.13

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
Sigma_EUR_phenotypes2_young_excluding_OLD_z3_5 Exclusive	60	59	CHURC1-FNTB
Ismael_14_AD Exclusive	13	13	
Overlap	1	1