Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
Sigma_EUR_phenotypes2_ADC_noOLD_86_z_3 Exclusive	ad_tier1_31	5.24e-01	4.69e-01	5.95e-01	3.60e-02
ad_tier1_31 Exclusive	Sigma_EUR_phenotypes2_ADC_noOLD_86_z_3	2.01e-01	7.95e-01	3.16e-01	6.63e-01
Sigma_EUR_phenotypes2_ADC_noOLD_86_z_3 Exclusive	ad_tier1_31 Exclusive	5.95e-01	5.46e-01	6.25e-01	3.48e-02
ad_tier1_31 Exclusive	Sigma_EUR_phenotypes2_ADC_noOLD_86_z_3 Exclusive	2.02e-01	7.52e-01	6.28e-01	9.64e-01
Sigma_EUR_phenotypes2_ADC_noOLD_86_z_3 Exclusive	Overlap	5.62e-01	4.87e-01	7.30e-01	8.15e-02
ad_tier1_31 Exclusive	Overlap	1.83e-09	1.83e-09	1.83e-09	6.04e-07
Overlap	Exclusives	1.96e-03	1.59e-04	1.65e-14	5.05e-05



Evaluating how well Sigma_EUR_phenotypes2_ADC_noOLD_86_z_3 genes are linked to ad_tier1_31 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Sigma_EUR_phenotypes2_ADC_noOLD_86_z_3 Exclusive	ad_tier1_31	0.59	0.08	0.07	0.03	1.31
ad_tier1_31 Exclusive	Sigma_EUR_phenotypes2_ADC_noOLD_86_z_3	0.51	0.18	-0.06	0.17	0.80
Sigma_EUR_phenotypes2_ADC_noOLD_86_z_3 Exclusive	ad_tier1_31 Exclusive	0.57	-0.12	-0.21	-0.05	1.26
ad_tier1_31 Exclusive	Sigma_EUR_phenotypes2_ADC_noOLD_86_z_3 Exclusive	0.50	-0.21	-0.37	-0.16	-0.11
Sigma_EUR_phenotypes2_ADC_noOLD_86_z_3 Exclusive	Overlap	0.73	0.88	0.28	0.49	1.82
ad_tier1_31 Exclusive	Overlap	1.00	2.71	3.12	2.74	3.55
Overlap	Exclusives	0.61	4.79	4.83	3.41	5.13

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Sigma_EUR_phenotypes2_ADC_noOLD_86_z_3 Exclusive	ad_tier1_31	0.00	-0.47	-0.77	-0.31	-0.01
ad_tier1_31 Exclusive	Sigma_EUR_phenotypes2_ADC_noOLD_86_z_3	0.01	3.27	2.53	1.95	3.88
Sigma_EUR_phenotypes2_ADC_noOLD_86_z_3 Exclusive	ad_tier1_31 Exclusive	0.00	-0.37	-0.66	-0.39	0.01
ad_tier1_31 Exclusive	Sigma_EUR_phenotypes2_ADC_noOLD_86_z_3 Exclusive	0.01	-0.26	-0.24	-0.20	-0.34
Sigma_EUR_phenotypes2_ADC_noOLD_86_z_3 Exclusive	Overlap	0.00	-0.38	-0.86	-0.30	0.06
ad_tier1_31 Exclusive	Overlap	0.05	115.82	196.33	108.35	22.84
Overlap	Exclusives	0.03	34.71	38.99	14.07	39.32

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
Sigma_EUR_phenotypes2_ADC_noOLD_86_z_3 Exclusive	107	104	CHURC1-FNTB;AC139530.2;TMEM191C
ad_tier1_31 Exclusive	27	26	MS4A
Overlap	4	4