Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
Sigma_EUR_phenotypes2_ADC_noOLD_86_z_3	Ismael_14_AD	6.84e-01	3.33e-01	3.23e-01	4.38e-03
Ismael_14_AD	Sigma_EUR_phenotypes2_ADC_noOLD_86_z_3	3.86e-01	6.01e-01	4.21e-06	4.06e-01



Evaluating how well Sigma_EUR_phenotypes2_ADC_noOLD_86_z_3 genes are linked to Ismael_14_AD genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Sigma_EUR_phenotypes2_ADC_noOLD_86_z_3	Ismael_14_AD	0.75	0.45	1.35	1.31	3.05
Ismael_14_AD	Sigma_EUR_phenotypes2_ADC_noOLD_86_z_3	0.54	1.05	1.22	1.58	1.50

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Sigma_EUR_phenotypes2_ADC_noOLD_86_z_3	Ismael_14_AD	0.00	0.04	0.56	1.34	5.44
Ismael_14_AD	Sigma_EUR_phenotypes2_ADC_noOLD_86_z_3	0.01	1.08	0.66	0.50	0.64

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
Sigma_EUR_phenotypes2_ADC_noOLD_86_z_3	111	108	AC139530.2;CHURC1-FNTB;TMEM191C
Ismael_14_AD	14	14