Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
Sigma_EUR_phenotypes2_ADC_noOLD_86_z_3_5 Exclusive	ad_tier1_31	4.34e-01	4.00e-01	5.21e-01	2.76e-02
ad_tier1_31 Exclusive	Sigma_EUR_phenotypes2_ADC_noOLD_86_z_3_5	1.79e-01	6.49e-01	4.44e-01	7.16e-01
Sigma_EUR_phenotypes2_ADC_noOLD_86_z_3_5 Exclusive	ad_tier1_31 Exclusive	6.64e-01	6.31e-01	8.14e-01	1.28e-01
ad_tier1_31 Exclusive	Sigma_EUR_phenotypes2_ADC_noOLD_86_z_3_5 Exclusive	1.46e-01	6.15e-01	5.93e-01	6.98e-01
Sigma_EUR_phenotypes2_ADC_noOLD_86_z_3_5 Exclusive	Overlap	3.41e-01	4.46e-01	3.99e-01	7.27e-02
ad_tier1_31 Exclusive	Overlap	1.83e-09	1.83e-09	1.83e-09	2.74e-08
Overlap	Exclusives	1.87e-06	4.31e-07	2.92e-13	1.06e-07



Evaluating how well Sigma_EUR_phenotypes2_ADC_noOLD_86_z_3_5 genes are linked to ad_tier1_31 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Sigma_EUR_phenotypes2_ADC_noOLD_86_z_3_5 Exclusive	ad_tier1_31	0.59	0.03	-0.13	0.01	1.80
ad_tier1_31 Exclusive	Sigma_EUR_phenotypes2_ADC_noOLD_86_z_3_5	0.52	-0.44	-0.41	0.03	0.47
Sigma_EUR_phenotypes2_ADC_noOLD_86_z_3_5 Exclusive	ad_tier1_31 Exclusive	0.56	-0.40	-0.41	-0.27	1.07
ad_tier1_31 Exclusive	Sigma_EUR_phenotypes2_ADC_noOLD_86_z_3_5 Exclusive	0.47	-1.34	-0.97	-1.19	-0.54
Sigma_EUR_phenotypes2_ADC_noOLD_86_z_3_5 Exclusive	Overlap	0.80	1.20	1.00	1.28	1.74
ad_tier1_31 Exclusive	Overlap	1.00	2.91	2.38	2.95	3.42
Overlap	Exclusives	0.70	4.91	6.51	5.06	6.04

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Sigma_EUR_phenotypes2_ADC_noOLD_86_z_3_5 Exclusive	ad_tier1_31	0.00	-0.49	-0.66	-0.31	0.23
ad_tier1_31 Exclusive	Sigma_EUR_phenotypes2_ADC_noOLD_86_z_3_5	0.01	1.83	8.29	2.01	10.21
Sigma_EUR_phenotypes2_ADC_noOLD_86_z_3_5 Exclusive	ad_tier1_31 Exclusive	0.00	-0.56	-0.73	-0.49	-0.20
ad_tier1_31 Exclusive	Sigma_EUR_phenotypes2_ADC_noOLD_86_z_3_5 Exclusive	0.00	-0.30	-0.67	-0.32	-0.25
Sigma_EUR_phenotypes2_ADC_noOLD_86_z_3_5 Exclusive	Overlap	0.00	0.08	-0.06	0.30	0.26
ad_tier1_31 Exclusive	Overlap	0.05	115.21	115.37	133.53	181.98
Overlap	Exclusives	0.04	25.16	87.94	65.30	85.63

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
Sigma_EUR_phenotypes2_ADC_noOLD_86_z_3_5 Exclusive	48	45	CHURC1-FNTB;TMEM191C;AC139530.2
ad_tier1_31 Exclusive	27	26	MS4A
Overlap	4	4