Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
Sigma_EUR_phenotypes2_ADC_noOLD_86_z_3_5	Ismael_14_AD	1.05e-02	1.36e-02	1.26e-03	1.85e-05
Ismael_14_AD	Sigma_EUR_phenotypes2_ADC_noOLD_86_z_3_5	6.54e-01	8.55e-01	6.33e-03	6.28e-01



Evaluating how well Sigma_EUR_phenotypes2_ADC_noOLD_86_z_3_5 genes are linked to Ismael_14_AD genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Sigma_EUR_phenotypes2_ADC_noOLD_86_z_3_5	Ismael_14_AD	0.83	1.92	3.53	2.35	4.08
Ismael_14_AD	Sigma_EUR_phenotypes2_ADC_noOLD_86_z_3_5	0.55	0.99	0.81	1.05	1.27

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Sigma_EUR_phenotypes2_ADC_noOLD_86_z_3_5	Ismael_14_AD	0.00	3.74	8.55	6.41	2.82
Ismael_14_AD	Sigma_EUR_phenotypes2_ADC_noOLD_86_z_3_5	0.00	0.53	3.26	2.47	3.62

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
Sigma_EUR_phenotypes2_ADC_noOLD_86_z_3_5	52	49	AC139530.2;CHURC1-FNTB;TMEM191C
Ismael_14_AD	14	14