Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
sigma_122 Exclusive	lipid_gs	2.08e-02	5.51e-03	5.28e-04	3.59e-07
lipid_gs Exclusive	sigma_122	3.30e-01	2.96e-02	4.31e-04	5.89e-04
sigma_122 Exclusive	lipid_gs Exclusive	5.95e-02	2.91e-03	9.75e-04	1.42e-06
lipid_gs Exclusive	sigma_122 Exclusive	4.40e-01	3.37e-02	1.14e-04	9.73e-04
sigma_122 Exclusive	Overlap	1.98e-02	1.98e-02	1.98e-02	1.98e-02
lipid_gs Exclusive	Overlap	1.98e-02	1.98e-02	1.98e-02	3.96e-02
Overlap	Exclusives	2.41e-01	2.18e-03	4.01e-36	1.63e-04



Evaluating how well sigma_122 genes are linked to lipid_gs genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
sigma_122 Exclusive	lipid_gs	0.85	2.52	3.67	2.53	5.06
lipid_gs Exclusive	sigma_122	0.58	1.66	1.88	2.31	3.23
sigma_122 Exclusive	lipid_gs Exclusive	0.84	1.88	4.31	2.20	6.04
lipid_gs Exclusive	sigma_122 Exclusive	0.57	1.69	2.12	2.07	2.86
sigma_122 Exclusive	Overlap	1.00	1.16	inf	1.18	1.80
lipid_gs Exclusive	Overlap	1.00	1.75	452597312996971.00	2.12	1.63
Overlap	Exclusives	0.61	inf	2.95	2.33	4.84

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
sigma_122 Exclusive	lipid_gs	0.02	14.09	17.50	14.20	21.86
lipid_gs Exclusive	sigma_122	0.02	20.10	25.07	26.89	28.88
sigma_122 Exclusive	lipid_gs Exclusive	0.01	7.02	12.89	10.58	7.16
lipid_gs Exclusive	sigma_122 Exclusive	0.02	17.24	26.51	14.90	29.08
sigma_122 Exclusive	Overlap	0.01	12.75	8068786864853115.00	10.97	48.13
lipid_gs Exclusive	Overlap	0.02	50.84	166182257993505280.00	92.61	7.76
Overlap	Exclusives	0.02	inf	20.90	10.45	25.54

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
sigma_122 Exclusive	121	120	RFPL2
lipid_gs Exclusive	19	19	
Overlap	1	1