Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
Common to Males Females Exclusive	Lipid Droplet genes	8.34e-04	6.28e-04	1.34e-03	7.68e-08
Lipid Droplet genes Exclusive	Common to Males Females	2.09e-01	2.49e-01	8.49e-02	2.85e-01
Common to Males Females Exclusive	Lipid Droplet genes Exclusive	5.66e-04	2.40e-04	1.83e-03	2.50e-07
Lipid Droplet genes Exclusive	Common to Males Females Exclusive	4.97e-01	2.94e-01	4.44e-02	6.25e-01
Common to Males Females Exclusive	Overlap	1.98e-02	1.98e-02	1.98e-02	1.98e-02
Lipid Droplet genes Exclusive	Overlap	1.98e-02	1.98e-02	1.98e-02	1.98e-02
Overlap	Exclusives	4.45e-05	7.77e-08	5.86e-19	3.39e-09



Evaluating how well Common to Males Females genes are linked to Lipid Droplet genes genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Common to Males Females Exclusive	Lipid Droplet genes	0.86	3.19	4.80	2.43	5.75
Lipid Droplet genes Exclusive	Common to Males Females	0.61	1.50	1.56	1.66	1.40
Common to Males Females Exclusive	Lipid Droplet genes Exclusive	0.85	2.92	4.43	2.57	4.86
Lipid Droplet genes Exclusive	Common to Males Females Exclusive	0.58	1.39	2.11	2.02	0.85
Common to Males Females Exclusive	Overlap	0.99	1.76	inf	1.81	1.81
Lipid Droplet genes Exclusive	Overlap	1.00	1.63	452597312996971.00	1.95	1.66
Overlap	Exclusives	0.82	852675310081127.00	6.81	3.26	6.39

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Common to Males Females Exclusive	Lipid Droplet genes	0.01	8.39	33.91	13.33	8.73
Lipid Droplet genes Exclusive	Common to Males Females	0.03	60.31	30.28	69.17	62.38
Common to Males Females Exclusive	Lipid Droplet genes Exclusive	0.01	19.12	29.37	17.02	19.03
Lipid Droplet genes Exclusive	Common to Males Females Exclusive	0.02	47.19	32.11	28.87	43.00
Common to Males Females Exclusive	Overlap	0.00	18.30	23954641353032980.00	9.11	10.51
Lipid Droplet genes Exclusive	Overlap	0.02	54.50	166182257993505280.00	84.04	68.54
Overlap	Exclusives	0.02	34136733995077676.00	45.75	15.55	27.47

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
Common to Males Females Exclusive	14	14	
Lipid Droplet genes Exclusive	19	19	
Overlap	1	1