Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
female_sigma_genes_69 Exclusive	lipid_gs	9.71e-02	1.51e-01	7.74e-02	7.88e-04
lipid_gs Exclusive	female_sigma_genes_69	2.90e-02	8.84e-01	4.02e-02	9.20e-01
female_sigma_genes_69 Exclusive	lipid_gs Exclusive	2.88e-01	1.40e-01	1.39e-01	1.83e-03
lipid_gs Exclusive	female_sigma_genes_69 Exclusive	2.80e-02	8.35e-01	2.59e-02	9.50e-01
female_sigma_genes_69 Exclusive	Overlap	3.96e-02	1.98e-02	1.98e-02	5.94e-02
lipid_gs Exclusive	Overlap	1.98e-02	1.98e-02	1.98e-02	1.98e-02
Overlap	Exclusives	6.59e-02	5.90e-04	1.47e-27	6.95e-05



Evaluating how well female_sigma_genes_69 genes are linked to lipid_gs genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
female_sigma_genes_69 Exclusive	lipid_gs	0.75	0.96	1.95	1.26	3.89
lipid_gs Exclusive	female_sigma_genes_69	0.51	-0.21	-0.16	0.11	0.21
female_sigma_genes_69 Exclusive	lipid_gs Exclusive	0.74	0.70	2.18	1.19	3.39
lipid_gs Exclusive	female_sigma_genes_69 Exclusive	0.50	-0.51	-0.21	0.03	0.16
female_sigma_genes_69 Exclusive	Overlap	0.99	1.35	inf	1.33	1.56
lipid_gs Exclusive	Overlap	1.00	1.59	452597312996971.00	1.87	1.70
Overlap	Exclusives	0.64	304382161419753.00	4.33	2.56	4.81

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
female_sigma_genes_69 Exclusive	lipid_gs	0.00	2.87	4.50	2.35	6.53
lipid_gs Exclusive	female_sigma_genes_69	0.01	9.01	5.80	3.45	9.43
female_sigma_genes_69 Exclusive	lipid_gs Exclusive	0.00	1.11	3.72	2.47	0.22
lipid_gs Exclusive	female_sigma_genes_69 Exclusive	0.01	7.55	4.12	6.84	2.48
female_sigma_genes_69 Exclusive	Overlap	0.00	6.14	5596706333042947.00	6.74	4.27
lipid_gs Exclusive	Overlap	0.02	37.15	166182257993505280.00	76.63	27.66
Overlap	Exclusives	0.01	6927426348784749.00	13.68	4.90	14.24

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
female_sigma_genes_69 Exclusive	69	67	RAB6D;RFPL2
lipid_gs Exclusive	19	19	
Overlap	1	1