Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
male_sigma_genes_82 Exclusive	lipid_gs	2.85e-02	2.66e-02	1.16e-02	2.66e-06
lipid_gs Exclusive	male_sigma_genes_82	3.08e-01	6.57e-01	1.08e-02	3.53e-01
male_sigma_genes_82 Exclusive	lipid_gs Exclusive	7.78e-02	2.23e-02	1.30e-02	3.23e-06
lipid_gs Exclusive	male_sigma_genes_82 Exclusive	2.81e-01	7.43e-01	2.66e-02	4.19e-01
male_sigma_genes_82 Exclusive	Overlap	1.98e-02	1.98e-02	1.98e-02	3.96e-02
lipid_gs Exclusive	Overlap	1.98e-02	1.98e-02	1.98e-02	1.98e-02
Overlap	Exclusives	3.73e-02	3.83e-03	3.62e-30	3.62e-04



Evaluating how well male_sigma_genes_82 genes are linked to lipid_gs genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
male_sigma_genes_82 Exclusive	lipid_gs	0.82	1.72	3.60	2.21	4.49
lipid_gs Exclusive	male_sigma_genes_82	0.54	1.10	1.11	1.25	1.09
male_sigma_genes_82 Exclusive	lipid_gs Exclusive	0.82	1.76	3.46	2.08	4.47
lipid_gs Exclusive	male_sigma_genes_82 Exclusive	0.54	0.86	0.72	0.94	0.95
male_sigma_genes_82 Exclusive	Overlap	1.00	1.18	237080781962084.00	1.17	1.71
lipid_gs Exclusive	Overlap	1.00	1.91	452597312996971.00	1.95	1.77
Overlap	Exclusives	0.63	inf	4.37	2.90	4.37

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
male_sigma_genes_82 Exclusive	lipid_gs	0.01	7.23	15.18	13.08	18.16
lipid_gs Exclusive	male_sigma_genes_82	0.03	17.37	23.62	13.76	36.16
male_sigma_genes_82 Exclusive	lipid_gs Exclusive	0.01	5.31	9.86	6.49	6.20
lipid_gs Exclusive	male_sigma_genes_82 Exclusive	0.03	30.27	28.77	35.86	39.16
male_sigma_genes_82 Exclusive	Overlap	0.01	7.27	44078968617424888.00	12.14	7.35
lipid_gs Exclusive	Overlap	0.02	83.99	166182257993505280.00	78.23	28.20
Overlap	Exclusives	0.01	2835763339405841.00	17.64	7.57	12.99

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
male_sigma_genes_82 Exclusive	81	81	
lipid_gs Exclusive	19	19	
Overlap	1	1