Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
Sigma_EUR_phenotypes2_excluding_PITT_MIA_KGAD_STEP_age_86_z_3	Ismael_14_AD	4.20e-01	3.97e-01	5.70e-01	3.96e-03
Ismael_14_AD	Sigma_EUR_phenotypes2_excluding_PITT_MIA_KGAD_STEP_age_86_z_3	3.64e-01	7.39e-01	4.24e-06	6.54e-01



Evaluating how well Sigma_EUR_phenotypes2_excluding_PITT_MIA_KGAD_STEP_age_86_z_3 genes are linked to Ismael_14_AD genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Sigma_EUR_phenotypes2_excluding_PITT_MIA_KGAD_STEP_age_86_z_3	Ismael_14_AD	0.76	1.26	1.98	1.23	3.68
Ismael_14_AD	Sigma_EUR_phenotypes2_excluding_PITT_MIA_KGAD_STEP_age_86_z_3	0.52	1.90	0.99	1.37	1.00

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Sigma_EUR_phenotypes2_excluding_PITT_MIA_KGAD_STEP_age_86_z_3	Ismael_14_AD	0.00	0.45	2.30	0.62	3.95
Ismael_14_AD	Sigma_EUR_phenotypes2_excluding_PITT_MIA_KGAD_STEP_age_86_z_3	0.01	0.64	0.91	1.08	0.89

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
Sigma_EUR_phenotypes2_excluding_PITT_MIA_KGAD_STEP_age_86_z_3	114	112	AC139530.2;CHURC1-FNTB
Ismael_14_AD	14	14