Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
Sigma_EUR_phenotypes2_excluding_PITT_MIA_KGAD_STEP_age_86_z_3 Exclusive	tier1_31	2.53e-01	4.12e-01	2.11e-01	8.66e-02
tier1_31 Exclusive	Sigma_EUR_phenotypes2_excluding_PITT_MIA_KGAD_STEP_age_86_z_3	4.63e-01	6.59e-01	3.58e-01	8.92e-01
Sigma_EUR_phenotypes2_excluding_PITT_MIA_KGAD_STEP_age_86_z_3 Exclusive	tier1_31 Exclusive	4.78e-01	4.39e-01	3.40e-01	2.95e-01
tier1_31 Exclusive	Sigma_EUR_phenotypes2_excluding_PITT_MIA_KGAD_STEP_age_86_z_3 Exclusive	4.41e-01	6.69e-01	3.48e-01	7.41e-01
Sigma_EUR_phenotypes2_excluding_PITT_MIA_KGAD_STEP_age_86_z_3 Exclusive	Overlap	3.77e-01	2.76e-01	4.54e-01	3.73e-02
tier1_31 Exclusive	Overlap	1.83e-09	1.83e-09	2.74e-08	6.40e-08
Overlap	Exclusives	3.10e-03	4.35e-03	9.76e-11	4.57e-03



Evaluating how well Sigma_EUR_phenotypes2_excluding_PITT_MIA_KGAD_STEP_age_86_z_3 genes are linked to tier1_31 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Sigma_EUR_phenotypes2_excluding_PITT_MIA_KGAD_STEP_age_86_z_3 Exclusive	tier1_31	0.57	-0.68	-0.71	-0.44	1.37
tier1_31 Exclusive	Sigma_EUR_phenotypes2_excluding_PITT_MIA_KGAD_STEP_age_86_z_3	0.51	0.27	0.54	0.71	0.35
Sigma_EUR_phenotypes2_excluding_PITT_MIA_KGAD_STEP_age_86_z_3 Exclusive	tier1_31 Exclusive	0.54	-0.68	-1.32	-0.73	0.67
tier1_31 Exclusive	Sigma_EUR_phenotypes2_excluding_PITT_MIA_KGAD_STEP_age_86_z_3 Exclusive	0.49	-0.09	-0.19	0.24	-0.20
Sigma_EUR_phenotypes2_excluding_PITT_MIA_KGAD_STEP_age_86_z_3 Exclusive	Overlap	0.75	0.84	1.02	0.72	1.51
tier1_31 Exclusive	Overlap	1.00	2.65	2.87	2.76	3.57
Overlap	Exclusives	0.59	4.20	4.56	3.27	3.73

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Sigma_EUR_phenotypes2_excluding_PITT_MIA_KGAD_STEP_age_86_z_3 Exclusive	tier1_31	0.00	-0.92	-1.17	-0.55	-0.15
tier1_31 Exclusive	Sigma_EUR_phenotypes2_excluding_PITT_MIA_KGAD_STEP_age_86_z_3	0.01	2.25	3.04	3.06	1.13
Sigma_EUR_phenotypes2_excluding_PITT_MIA_KGAD_STEP_age_86_z_3 Exclusive	tier1_31 Exclusive	0.00	-0.75	-1.33	-0.62	-0.24
tier1_31 Exclusive	Sigma_EUR_phenotypes2_excluding_PITT_MIA_KGAD_STEP_age_86_z_3 Exclusive	0.01	-0.77	-0.78	-0.51	-0.49
Sigma_EUR_phenotypes2_excluding_PITT_MIA_KGAD_STEP_age_86_z_3 Exclusive	Overlap	0.00	-0.15	-0.34	-0.23	0.11
tier1_31 Exclusive	Overlap	0.05	74.45	119.29	106.81	202.60
Overlap	Exclusives	0.03	40.14	45.21	20.36	23.63

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
Sigma_EUR_phenotypes2_excluding_PITT_MIA_KGAD_STEP_age_86_z_3 Exclusive	110	108	CHURC1-FNTB;AC139530.2
tier1_31 Exclusive	27	26	MS4A
Overlap	4	4