Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
Sigma_EUR_phenotypes2_excluding_PITT_MIA_KGAD_STEP_age_86_z_3_5	Ismael_14_AD	3.25e-02	9.78e-02	2.31e-02	2.97e-05
Ismael_14_AD	Sigma_EUR_phenotypes2_excluding_PITT_MIA_KGAD_STEP_age_86_z_3_5	1.48e-01	4.45e-01	1.64e-04	4.90e-01



Evaluating how well Sigma_EUR_phenotypes2_excluding_PITT_MIA_KGAD_STEP_age_86_z_3_5 genes are linked to Ismael_14_AD genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Sigma_EUR_phenotypes2_excluding_PITT_MIA_KGAD_STEP_age_86_z_3_5	Ismael_14_AD	0.80	2.22	2.47	1.95	4.19
Ismael_14_AD	Sigma_EUR_phenotypes2_excluding_PITT_MIA_KGAD_STEP_age_86_z_3_5	0.52	0.16	0.72	0.85	0.65

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Sigma_EUR_phenotypes2_excluding_PITT_MIA_KGAD_STEP_age_86_z_3_5	Ismael_14_AD	0.00	1.14	2.42	1.04	5.15
Ismael_14_AD	Sigma_EUR_phenotypes2_excluding_PITT_MIA_KGAD_STEP_age_86_z_3_5	0.00	1.86	2.16	1.77	1.19

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
Sigma_EUR_phenotypes2_excluding_PITT_MIA_KGAD_STEP_age_86_z_3_5	55	54	CHURC1-FNTB
Ismael_14_AD	14	14