Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
Sigma_EUR_phenotypes2_excluding_PITT_MIA_KGAD_STEP_age_86_z_3_5 Exclusive	tier1_31	5.21e-01	8.33e-01	6.20e-01	4.52e-01
tier1_31 Exclusive	Sigma_EUR_phenotypes2_excluding_PITT_MIA_KGAD_STEP_age_86_z_3_5	5.60e-01	6.62e-01	2.40e-01	7.33e-01
Sigma_EUR_phenotypes2_excluding_PITT_MIA_KGAD_STEP_age_86_z_3_5 Exclusive	tier1_31 Exclusive	3.35e-01	8.77e-01	3.89e-01	6.31e-01
tier1_31 Exclusive	Sigma_EUR_phenotypes2_excluding_PITT_MIA_KGAD_STEP_age_86_z_3_5 Exclusive	3.71e-01	3.84e-01	3.19e-01	4.53e-01
Sigma_EUR_phenotypes2_excluding_PITT_MIA_KGAD_STEP_age_86_z_3_5 Exclusive	Overlap	2.11e-01	1.01e-01	1.21e-01	2.36e-01
tier1_31 Exclusive	Overlap	1.83e-09	1.83e-09	1.83e-09	2.74e-08
Overlap	Exclusives	2.58e-04	3.40e-04	1.16e-06	9.69e-05



Evaluating how well Sigma_EUR_phenotypes2_excluding_PITT_MIA_KGAD_STEP_age_86_z_3_5 genes are linked to tier1_31 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Sigma_EUR_phenotypes2_excluding_PITT_MIA_KGAD_STEP_age_86_z_3_5 Exclusive	tier1_31	0.56	-0.58	-0.59	-0.34	0.95
tier1_31 Exclusive	Sigma_EUR_phenotypes2_excluding_PITT_MIA_KGAD_STEP_age_86_z_3_5	0.53	0.95	0.76	0.91	0.71
Sigma_EUR_phenotypes2_excluding_PITT_MIA_KGAD_STEP_age_86_z_3_5 Exclusive	tier1_31 Exclusive	0.55	-0.71	-0.46	-0.37	0.86
tier1_31 Exclusive	Sigma_EUR_phenotypes2_excluding_PITT_MIA_KGAD_STEP_age_86_z_3_5 Exclusive	0.49	0.09	-0.14	0.22	-0.28
Sigma_EUR_phenotypes2_excluding_PITT_MIA_KGAD_STEP_age_86_z_3_5 Exclusive	Overlap	0.60	-0.67	-0.85	-0.56	0.90
tier1_31 Exclusive	Overlap	1.00	3.04	2.98	2.77	3.29
Overlap	Exclusives	0.62	3.64	3.41	2.10	3.59

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Sigma_EUR_phenotypes2_excluding_PITT_MIA_KGAD_STEP_age_86_z_3_5 Exclusive	tier1_31	0.00	-0.70	-0.79	-0.49	-0.12
tier1_31 Exclusive	Sigma_EUR_phenotypes2_excluding_PITT_MIA_KGAD_STEP_age_86_z_3_5	0.01	7.77	8.71	5.02	8.13
Sigma_EUR_phenotypes2_excluding_PITT_MIA_KGAD_STEP_age_86_z_3_5 Exclusive	tier1_31 Exclusive	0.00	-0.82	-0.76	-0.48	-0.29
tier1_31 Exclusive	Sigma_EUR_phenotypes2_excluding_PITT_MIA_KGAD_STEP_age_86_z_3_5 Exclusive	0.00	-0.33	-0.65	-0.21	-0.55
Sigma_EUR_phenotypes2_excluding_PITT_MIA_KGAD_STEP_age_86_z_3_5 Exclusive	Overlap	0.00	-0.64	-0.63	-0.57	-0.25
tier1_31 Exclusive	Overlap	0.05	136.65	143.16	161.70	115.81
Overlap	Exclusives	0.04	60.49	74.20	41.50	58.45

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
Sigma_EUR_phenotypes2_excluding_PITT_MIA_KGAD_STEP_age_86_z_3_5 Exclusive	51	50	CHURC1-FNTB
tier1_31 Exclusive	27	26	MS4A
Overlap	4	4