Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
Sigma_EUR_phenotypes2_young2_excluding_OLD_younger_than_85_z_3_5 Exclusive	Ismael_14_AD	3.08e-04	8.62e-05	2.06e-04	1.50e-05
Ismael_14_AD Exclusive	Sigma_EUR_phenotypes2_young2_excluding_OLD_younger_than_85_z_3_5	3.62e-01	6.65e-01	1.07e-03	5.28e-01
Sigma_EUR_phenotypes2_young2_excluding_OLD_younger_than_85_z_3_5 Exclusive	Ismael_14_AD Exclusive	1.63e-03	5.87e-04	1.21e-03	3.94e-05
Ismael_14_AD Exclusive	Sigma_EUR_phenotypes2_young2_excluding_OLD_younger_than_85_z_3_5 Exclusive	2.88e-01	8.09e-01	4.00e-03	6.10e-01
Sigma_EUR_phenotypes2_young2_excluding_OLD_younger_than_85_z_3_5 Exclusive	Overlap	1.98e-02	1.98e-02	3.96e-02	7.92e-02
Ismael_14_AD Exclusive	Overlap	1.98e-02	1.98e-02	1.98e-02	1.98e-02
Overlap	Exclusives	8.01e-04	1.70e-04	3.04e-04	4.24e-04



Evaluating how well Sigma_EUR_phenotypes2_young2_excluding_OLD_younger_than_85_z_3_5 genes are linked to Ismael_14_AD genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Sigma_EUR_phenotypes2_young2_excluding_OLD_younger_than_85_z_3_5 Exclusive	Ismael_14_AD	0.84	2.72	3.81	2.30	4.28
Ismael_14_AD Exclusive	Sigma_EUR_phenotypes2_young2_excluding_OLD_younger_than_85_z_3_5	0.54	1.27	0.66	0.71	1.07
Sigma_EUR_phenotypes2_young2_excluding_OLD_younger_than_85_z_3_5 Exclusive	Ismael_14_AD Exclusive	0.83	2.07	3.39	1.88	4.54
Ismael_14_AD Exclusive	Sigma_EUR_phenotypes2_young2_excluding_OLD_younger_than_85_z_3_5 Exclusive	0.53	0.58	0.36	0.69	0.89
Sigma_EUR_phenotypes2_young2_excluding_OLD_younger_than_85_z_3_5 Exclusive	Overlap	0.98	1.99	2.07	1.78	1.77
Ismael_14_AD Exclusive	Overlap	1.00	5.13	1.50	1.96	1.74
Overlap	Exclusives	0.56	0.32	0.49	0.73	1.83

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Sigma_EUR_phenotypes2_young2_excluding_OLD_younger_than_85_z_3_5 Exclusive	Ismael_14_AD	0.00	5.59	5.01	3.63	2.11
Ismael_14_AD Exclusive	Sigma_EUR_phenotypes2_young2_excluding_OLD_younger_than_85_z_3_5	0.01	13.72	9.11	11.48	11.87
Sigma_EUR_phenotypes2_young2_excluding_OLD_younger_than_85_z_3_5 Exclusive	Ismael_14_AD Exclusive	0.00	1.50	2.91	1.64	6.27
Ismael_14_AD Exclusive	Sigma_EUR_phenotypes2_young2_excluding_OLD_younger_than_85_z_3_5 Exclusive	0.00	1.39	3.74	3.47	0.76
Sigma_EUR_phenotypes2_young2_excluding_OLD_younger_than_85_z_3_5 Exclusive	Overlap	0.00	5.85	16.49	4.05	0.43
Ismael_14_AD Exclusive	Overlap	0.25	1596.50	479.85	383.69	1236.45
Overlap	Exclusives	0.02	20.71	40.40	27.62	13.11

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
Sigma_EUR_phenotypes2_young2_excluding_OLD_younger_than_85_z_3_5 Exclusive	62	61	CHURC1-FNTB
Ismael_14_AD Exclusive	13	13	
Overlap	1	1